Hypersensitivity to penicillins; renal impairment; Porphyria. Monitor renal and haematologic status.
Lactation: excretion in milk unknown; use with caution
Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.
Mode of Action
Ceftibuten inhibits bacterial cell wall synthesis. It is stable to hydrolysis by many beta-lactamases and has greater activity than 1st or 2nd generation cephalosporins against gm-ve bacteria. It is less active in vitro than cefexime against S. pneumoniae.
Pregnancy Category: B
Lactation: excretion in milk unknown; use with caution
Adult Dose
Oral
Respiratory tract infections, Urinary tract infections
Adult: 400 mg once daily for 10 days.
Child Dose
Child:
<6 months: Safety and efficacy not established
6-12 years old or <45 kg: 9 mg/kg PO qDay; 400 mg/day PO for 10 days maximum
>12 years old or >45 kg: As in adults
Renal Dose
Renal impairment:
CrCl (ml/min)
30-49 200 mg once daily.
5-29 100 mg once daily.
Administration
Susp: Should be taken on an empty stomach. Take 2 hr before or 1 hr after meals.
Cap: May be taken with or without food.
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