Indication:

Beriberi and Wernick's encephalopathy, neuritis associated with pregnancy and pellagra.

Dosage (breakdown or, not) :

Adult:

Treatment and prophylaxis of mild chronic thiamine deficiency Adult: 10-25 mg daily in single or divided doses. Thiamine deficiency Adult: 1 tablet (100mg) daily, up to 300 mg daily. Wernicke-Korsakoff syndrome Adult: Initially, 100 mg by slow IV Inj over 10 min, then 50-100 mg/day IM or IV until the patient can take oral thiamine.

Child:

Thiamine deficiency 10-50 mg/day PO in divided doses Beriberi 10-25 mg IV/IM qDay (if crtically ill) or 10-50 mg/dose PO qDay for at least 2 weeks, THEN 5-10 mg/day PO for 1 month

Administration

Should be taken with food.

Interaction:

May enhance the effect of neuromuscular blocking agents.

Contraindication

Hypersensitivity

Side Effect

IV: Warm sensation, tingling, pruritus, pain, urticaria, weakness, sweating, nausea, restlessness, tightness of the throat, angioedema, respiratory distress, cyanosis, pulmonary oedema, GI bleeding, transient vasodilation and hypotension, vascular collapse. IM: Tenderness and induration. Potentially Fatal: Very rarely, fatal anaphylactic shock.

Precaution

Parenteral admin. Increased daily requirements in pregnancy and lactation.