Generic Name

Rupatadine

Precaution

Renal or hepatic insufficiency. May impair ability to drive or operate machinery. Pregnancy, lactation. Elderly, children <12 yr.

Indication

Allergic rhinitis, Chronic idiopathic urticaria

Contra Indication

Hypersensitivity. Avoid alcohol.

Dose

N/A

Side Effect

Headache, somnolence, fatigue/asthenia.

Pregnancy Category

Mode of Action

Rupatadine acts as a long-acting, non-sedative antagonist at histaminergic H1-receptors. Rupatadine also antagonises the platelet-activating factor (PAF). Both histamine and PAF cause bronchoconstriction and lead to an increase in the vascular permeability, acting as mediators in the inflammatory process.

Interaction

Increased CNS depressant effects when used with CNS depressants or alcohol.

Pregnancy Category Note

N/A

Adult Dose

Oral Allergic rhinitis; Chronic idiopathic urticaria Adult: 10 mg (1 tablet) once daily.

Child Dose

Oral Allergic rhinitis; Chronic idiopathic urticaria Tablet Child > 12 years: 10 mg (1 tablet) once daily. Children: Use of Rupatadine is not recommended in patients less than 12 years of age. Syrup: Children aged 2 to 11 years: Children weighing 10 kg to less than 25 kg: 1/2 teaspoonful (2.5 ml) syrup once a day with or without food. Children weighing 25 kg or more: 1 teaspoonful (5ml) of syrup once a day with or without food.

Renal Dose

N/A

Administration

N/A