Indication

Acne vulgaris, erythrasma, rosacea, periorificial dermatitis, folliculitis, stasis, chronic lymphaedema and familial pemphigus, dermal ulcers.

Adult Dose

Topical/Cutaneous Acne Adult: As 1% preparation: Apply a thin layer onto affected area bid.

Child Dose

<12 years old Safety and efficacy not established >12 years: Apply a thin layer onto affected area bid.

Contraindication

Contraindicated in patients with hypersensitivity to clindamycin.

Mode of Action

Clindamycin inhibits protein synthesis by reversibly binding to the 50S subunit of the ribosomal thus blocking the transpeptidation or translocation reactions of susceptible organisms resulting to stunted cell growth.

Precautions & Warnings

Clindamycin lotion has an unpleasant taste and caution should be exercised when applying medication around the mouth. Clindamycin lotion may cause burning and irritation of the eye. In the event of accidental contact with sensitive surfaces (eye, abraded skin, mucous membranes), wash with copious amounts of cool tap water.

Pregnancy & Lactation
Pregnancy category B. There are no adequate and well controlled studies in pregnant woman. This drug should be used during pregnancy only if clearly needed. It is not known whether Clindamycin is excreted in human milk following use of Clindamycin topical lotion.

However, orally and parenterally administered Clindamycin has been reported to appear in breast milk. Caution should be exercised when topical Clindamycin lotion is administered to a nursing woman.

Interaction 

Clindamycin has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents. Therefore it should be used with caution in patients receiving such agents. Simultaneous use of other anti-acne or comedogenic cosmetic products should be avoided.

Storage Conditions
Store in a cool (below 25°C) & dry place. Protect from light. Keep away from the reach of children. Do not freeze.