Indications:
Fever, Mild to moderate pain, osteoarthritis, rheumatoid arthritis, chronic low back pain, Renal stone pain, neuropathic pain, toothache, migraine, postoperative mild to moderate pain.
Pharmacology:
Paracetamol is an analgesic and antipyretic with just a little anti-inflammatory effect. Paracetamol (Acetaminophen) is considered to work largely in the central nervous system (CNS), raising pain threshold by blocking both isoforms of the cyclooxygenase enzymes COX-1, COX-2, and COX-3, which are involved in prostaglandin (PG) production. Paracetamol is a para aminophenol derivative that possesses analgesic, antipyretic, and anti-inflammatory effects. One of the most commonly used, safest, and fastest acting analgesics is paracetamol. It is well tolerated and devoid of aspirin's numerous adverse effects.
Dosage (breakdown or, not) :
Adult:Â
 1-2 tablets every 4 to 6 hours up to a maximum of 4 gm (8 tablets) daily.
Child:Â
½ to 1 tablet 3 to 4 times daily. For long term treatment it is wise not to exceed the dose beyond 2.6 gm/day.
Administration:
Extended Release Tablet:
Interaction:
Extended Release Tablet:
Contraindication:
It is contraindicated in known hypersensitivity to Paracetamol.
Side Effects:Â
Although haematological responses such as thrombocytopenia, leucopenia, pancytopenia, neutropenia, and agranulocytosis have been described, paracetamol's side effects are typically moderate. Pancreatitis, rashes, and other allergic responses can happen at any time.
Pregnancy:Â
It is not recommended if you have a known hypersensitivity to paracetamol.
Precautions & Warnings:Â
Patients with poor kidney or liver function should use paracetamol with care. Patients taking other medications that damage the liver should use caution when using paracetamol.
Storage Conditions:
Keep below 30°C temperature in a dry place. Protected from light. Do not freeze. Keep out of reach of children.
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