Perkirol .25mg

Tablet

Pack Size : 10 Tablet x 1 Strip

Generics : Ropinirole

Manufacturer : Square Pharmaceuticals Ltd.

Best Price * TK 20.10

* Delivery will be done in Dhaka city only.

Alternative Product

Tablet Perkirol 2mg Square Pharmaceuticals Ltd.

Tk 6.04

More Information About - Perkirol .25mg

Description

Generic Name

Ropinirole

Precaution

Pregnancy. May impair ability to drive or operate machinery. Withdrawal should be gradual. Hepatic or renal impairment. May cause daytime sleepiness or episodes of falling asleep during activities. May cause or worsen pre-existing dyskinesia.

Indication

Parkinson's disease, Restless leg syndrome

Contra Indication

Lactation.

Dose

N/A

Side Effect

>10% Nausea (40-60%),Dizziness (6-40%),Somnolence (11-40%),Syncope (1-12%),Vomiting (12%),Fatigue (8-11%),Viral infection (11%),Dyspepsia (10%) 1-10% Hypertension (5%),Flushing (3%),Orthostasis (1-6%),Chest pain (4%),Palpitation (3%),Extrasystoles (2%),Tachycardia (2%),Hyperhidrosis (3%),Abnormal pain (3-7%),Anorexia (4%),Flatulence (3%),Malaise (3%),Hypoesthesia (4%),Urinary tract infection (5%),Impotence (3%),Alkaline phosphatase (3%),Abnormal vision (6%),Xerophthalmia (2%),Increased diaphoresis (3-6%) <1% Agitation,Aneurysm,Aphasia,Bradycardia,Cardiac arrest,Valvulopathy,Cellulitis,Colitis,Delusion,Delirium,Diaphoresis,Dyspnea,Ulceration,Glaucoma,Psychotic-like behavior,Impulse control/compulsive behavior,Withdrawal-emergent hyperpyrexia and confusion,Melanoma,Fibrotic complications

Pregnancy Category

Name : Not Classified

Description

FDA has not yet classified the drug into a specified pregnancy category.

Mode of Action

Ropinirole is a non-ergot dopamine D2-agonist with similar actions to those of bromocriptine. It is used in the management of Parkinson's disease, either alone or as an adjunct to levodopa.

Interaction

Inhibitors of CYP1A2 e.g. cimetidine, ciprofloxacin, erythromycin, fluvoxamine, isoniazid, ritonavir and zileuton may increase serum concentrations of ropinirole. Oestrogens and tobacco smoking may decrease clearance of ropinirole. Efficacy may be reduced by dopamine antagonists such as phenothiazines and metoclopramide.

Pregnancy Category Note

Pregnancy There are no adequate data on developmental risk associated with use in pregnant women; in animal studies, ropinirole had adverse effects on development when administered to pregnant rats at doses similar to (neurobehavioral impairment) or greater than (teratogenicity and embryolethality at >36 times) maximum recommended human dose (MRHD) for Parkinson?s disease Lactation There are no data on presence of ropinirole in human milk, the effects of ropinirole on breastfed infant, or effects of ropinirole on milk production; however, inhibition of lactation is expected because ropinirole inhibits secretion of prolactin in humans; ropinirole or metabolites, or both, are present in rat milk Developmental and health benefits of breastfeeding should be considered along with mother?s clinical need for therapy and any potential adverse effects on breastfed infant from ropinirole or from the underlying maternal condition

Adult Dose

Oral As monotherapy in Parkinson's disease Adult: Initially, 250 mcg tid, may increase by 750 mcg at wkly intervals for the first 4 wk. Subsequent increments can be made in steps of 1.5 mg at wkly intervals up to 9 mg/day, then in steps of 3 mg at wkly intervals. Usual dose ranges from 3-9 mg daily. Max: 24 mg/day. Higher dose may be necessary if used in conjunction with levodopa. Gradual withdrawal is recommended. Restless leg syndrome Adult: Initially, 250 mcg daily for 2 days, taken 1-3 hr before bedtime. May increase to 500 mcg daily for the next few days. Subsequent increments may be made in steps of 500 mcg at wkly intervals until 3 mg daily is reached. Max: 4 mg daily. Hepatic impairment: Dosing adjustments may be required.

Child Dose

N/A

Renal Dose

N/A

Administration

May be taken with or without food. May be taken w/ meals to reduce occurrence of nausea.

Disclaimer

The information provided herein are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please note that this information should not be treated as a replacement for physical medical consultation or advice. Great effort has been placed to provide accurate and comprehensive data. However, Medicart along with its authors and editors make no representations or warranties and specifically disclaim all liability for any medical information provided on the site. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company.