History of GI disease, asthma, hypertension, CVD or risk factors, fluid retention or heart failure. Monitor patients with advanced renal disease. May impair ability to drive or operate machinery. Elderly. Pregnancy (avoid in the 3rd trimester) and lactation.
Hypersensitivity to meloxicam, aspirin or other NSAIDs; severe hepatic impairment; bleeding disorders; renal failure without dialysis. Rectal admin in patients with proctitis, haemorrhoids or rectal bleeding.
Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks
Mode of Action
Meloxicam is an oxicam derivative which exhibits analgesic, antipyretic and anti-inflammatory actions. It reversibly inhibits the cyclooxygenase-1 and -2 (COX-1 and -2) enzymes, thus resulting in reduced synthesis of prostaglandin precursors.
Interaction
Increased risk of severe GI effects w/ aspirin or warfarin. May antagonise antihypertensive effects of ACE inhibitors and angiotensin II receptor antagonists. May reduce natriuretic effects of furosemide and thiazides. Enhanced toxicity of methotrexate. May increase plasma lithium concentration.
Pregnancy Category Note
Pregnancy category: C; D in third trimester of pregnancy; drug should be avoided in late pregnancy
Lactation: Unknown whether drug is excreted in breast milk; effect on infant unknown; not recommended
Adult Dose
Oral
Rheumatoid arthritis; Ankylosing spondylitis
Adult: 15 mg daily as a single dose. Patients w/ increased risk of adverse effects: Initially, 7.5 mg daily.
Acute exacerbations of osteoarthritis
Adult: 7.5 mg daily up to max 15 mg daily as a single dose.
Elderly: 7.5 mg daily for long-term treatment.
Child Dose
Oral
Juvenile rheumatoid arthritis
Child: >2 yr 0.125 mg/kg once daily. Max: 7.5 mg daily.
Renal Dose
Renal impairment: Mild to moderate: No dosage adjustment needed.
Severe: Not recommended.
Dialysis patient: 7.5 mg daily.
Administration
May be taken with or without food. May be taken w/ meals if GI discomfort occurs.
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The information provided herein are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please note that this information should not be treated as a replacement for physical medical consultation or advice. Great effort has been placed to provide accurate and comprehensive data. However, Medicart along with its authors and editors make no representations or warranties and specifically disclaim all liability for any medical information provided on the site. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company.