Ipratropium Bromide solution should not be taken by patients with known hypersensitivity to atropine or its derivatives or to any other component of the product.
Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.
Mode of Action
Ipratropium bromide blocks the action of acetylcholine at parasympathetic sites in bronchial smooth muscle causing bronchodilation.
Interaction
Increased toxicity with other anticholinergic drugs.
Pregnancy Category Note
Pregnancy category: B
Lactation: Unknown whether drug is excreted in breast milk
Adult Dose
Inhalation
Asthma; Chronic obstructive pulmonary disease
Adult: As Inhaler: Adults: 1-2 puffs (20 mg/puff) 3-4 times daily. Single doses of up to 80 mcg may be required in some patients.
As nebulized soln
250-500 mcg 3-4 times daily.
Child Dose
Inhalation
Asthma; Chronic obstructive pulmonary disease
Child: As metered-dose aerosol:
<6 yr 20 mcg tid;
6-12 yr 20-40 mcg tid.
As soln for nebulisation:
<6 yr For acute asthma: 125-250 mcg, given no more often than 6 hrly up to a total dose of 1 mg.
6-12 yr For acute and chronic asthma: 250 mcg, repeated as necessary up to a total dose of 1 mg.
Renal Dose
N/A
Administration
N/A
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