Emcil 200mg

Tablet

Pack Size : 6 Strip x 1 Strip

Generics : Pivmecillinam

Manufacturer : Square Pharmaceuticals Ltd.

Best Price * TK 90.30

* Delivery will be done in Dhaka city only.

Alternative Product

More Information About - Emcil 200mg

Description

Generic Name

Pivmecillinam

Precaution

Very high doses in poor renal function (risk of neurotoxicity) or heart failure. Avoid contact, skin sensitization may occur. Monitor serum K concentration, renal and haematological status. Spirochete infections particularly syphilis; suprainfection with penicillin-resistant organisms with prolonged use; avoid intrathecal route. May cause oesophageal injury.

Indication

Acute uncomplicated cystitis, Chronic or recurrent bacteriuria

Contra Indication

Hypersensitivity, porphyria.

Dose

N/A

Side Effect

Hypersensitivity reactions including uticaria; fever; joint pains; rashes; angioedema; serum sickness-like reactions; haemolytic anaemia; interstitial nephritis; neutropaenia; thrombocytopaenia; CNS toxicity including convulsions; diarrhoea; antibiotic-associated colitis. Induction of carnitine deficiency. Potentially Fatal: Anaphylaxis.

Pregnancy Category

Name : B

Description

Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.

Mode of Action

Pivmecillinam has the antimicrobial activity of mecillinam to which it is hydrolysed in vivo. It interferes with the synthesis of bacterial cell wall. It is active against many gm-ve bacteria, esp Enterobacteriaceae including Escherichia coli, Enterobacter, Klebsiella, Salmonella and Shigella spp; indole-positive Proteus and Serratia marcescens are resistant. It is inactivated by beta-lactamases, but is more stable than ampicillin.

Interaction

Probenecid prolongs T1/2 of pivmecillinam. May cause prolonged bleeding when taken with anticoagulants. May decrease the efficacy of oral contraceptives. Increased risk of carnitine deficiency when used with valproate.

Pregnancy Category Note

N/A

Adult Dose

Oral Acute uncomplicated cystitis Adult: Initially 400 mg followed by 200 mg tid for 8 doses. Chronic or recurrent bacteriuria Adult: 400 mg 3-4 times daily.

Child Dose

Oral Acute uncomplicated cystitis Child: <40 kg with UTI: 20-40 mg/kg/day in 3-4 divided doses. Chronic or recurrent bacteriuria Child: <40 kg with UTI: 20-40 mg/kg/day in 3-4 divided doses.

Renal Dose

N/A

Administration

N/A

Disclaimer

The information provided herein are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please note that this information should not be treated as a replacement for physical medical consultation or advice. Great effort has been placed to provide accurate and comprehensive data. However, Medicart along with its authors and editors make no representations or warranties and specifically disclaim all liability for any medical information provided on the site. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company.