There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Mode of Action
Oxytetracycline binds reversibly to the 30S and possibly 50S ribosomal subunits, thus inhibiting bacterial protein synthesis and arresting cell growth. It is active against a wide range of gram-positive and gram-negative organisms.
Interaction
Antacids, iron, aluminum, calcium, magnesium, zinc salts reduce absorption. Concurrent use may cause increased levels of lithium, digoxin, halofantrine and theophylline; decreased concentrations of atovaquone. Increased risk of ergotism with ergot alkaloids. May cause failure of oral contraception.
Potentially Fatal: Interferes with anticoagulant control. Nephrotoxic effects exacerbated by diuretics, methoxyflurane or other nephrotoxic drugs; avoid concurrent use with potentially hepatotoxic drugs. Increased incidence of benign intracranial hypertension with retinoids.
Pregnancy Category Note
N/A
Adult Dose
Oral
Susceptible infections
Adult: 250-500 mg 4 times daily. Max 4 g daily.
Acne
Adult: 250-500 mg bid.
Uncomplicated gonorrhoea
Adult: 1.5 g initially, followed by 0.5 g four times daily up to a total of 9 g per treatment course.
Intramuscular
Susceptible infections
Adult: 250 mg once daily or 300 mg daily in 2-3 divided doses.
Should be taken on an empty stomach. Take on an empty stomach 1 hr before or 2 hr after meals.
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