Diamine Penicillin 12 Lac Unit

Injection

Pack Size : 1 Bottle x 1 Packet

Generics : Benzathine Penicillin

Manufacturer : Renata Limited

Best Price * TK 24.21

Refrigerated

* Delivery will be done in Dhaka city only.

Alternative Product

More Information About - Diamine Penicillin 12 Lac Unit

Description

Generic Name

Benzathine Penicillin

Precaution

Very high doses in poor renal function (risk of neurotoxicity) or heart failure. Avoid contact, skin sensitization may occur. Monitor serum potassium concentration, renal and haematological status. Spirochete infections particularly syphilis; suprainfection with penicillin-resistant organisms with prolonged use; avoid intrathecal route. Lactation: Excreted into breast milk, caution advised

Indication

Acute otitis media, Group A Strep. infections, Rheumatic fever, Syphilis, Neurosyphilis, Streptococcal impetigo, Anthrax, Diphtheria, Uncomplicated pneumococcal pneumonia, Streptococcal pharyngitis

Contra Indication

Hypersensitivity to penicillins or cephalosporins. IM inj (ischaemic reactions may occur).

Dose

N/A

Side Effect

Hypersensitivity reactions including uticaria; fever; joint pains; rashes; angioedema; serum sickness-like reactions; haemolytic anaemia; interstitial nephritis; neutropenia; thrombocytopenia; CNS toxicity including convulsions; diarrhoea; antibiotic-associated colitis. Potentially Fatal: Anaphylaxis

Pregnancy Category

Name : B

Description

Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.

Mode of Action

Benzathine benzylpenicillin has the same antimicrobial action as benzylpenicillin which exerts its bactericidal action on growing and dividing bacteria by inhibiting bacterial cell wall synthesis. IM admin results in a prolonged effect, but because of its relatively low blood concentrations, its use should be restricted to microorganisms that are highly susceptible to it.

Interaction

Probenecid prolongs T1/2 of benzathine benzylpenicillin. Bacteriostatic drugs e.g. chloramphenicol, tetracyclines; other antibacterials; anticoagulants.

Pregnancy Category Note

Pregnancy Category: B Lactation: Excreted into breast milk, caution advised

Adult Dose

Adult: IM: 0.3 to 1.2 million units up to 2.4 million units as a single dose repeated every five to seven days. Specific dosage schedule: Treatment of group-A beta-haemolytic streptococcal infections: A single intramuscular dose of 600,000 units. Prevention of rheumatic fever: Monthly injection of a single dose of 1.2 million units is the most effective regimen for preventing further attacks of rheumatic fever. Treatment of acute otitis media: A single injection of 600,000 units. Treatment of syphilis: Early syphilis- 2.4 million units as a single dose. Late syphilis- 2.4 million units weekly for three successive weeks. Neurosyphilis- Benzylpenicillin, intravenously, 2 to 4 million units every 4 hours for 10 days, followed by benzathine penicillin intramuscularly, 2.4 million units weekly for three successive weeks. Congenital syphilis: Asymptomatic infants with normal cerebrospinal fluid, intramuscularly 50,000 units per kg in a single dose. Primary and secondary syphilis have been treated with single injections of 2.4 million units of long acting benzathine penicillin weekly for 2 to 4 weeks with satisfactory results.

Child Dose

Child: IM 50,000 U/kg for newborns and infants, Child: IM 50,000 U/kg for newborns and infants, children <60 lb: 300,000?600,000 U, children >60 lb: 900,000 U 1 dose for treatment

Renal Dose

N/A

Administration

N/A

Disclaimer

The information provided herein are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please note that this information should not be treated as a replacement for physical medical consultation or advice. Great effort has been placed to provide accurate and comprehensive data. However, Medicart along with its authors and editors make no representations or warranties and specifically disclaim all liability for any medical information provided on the site. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company.