Nalid PFS 50ml 300mg/5ml

Suspension

Pack Size : 1 Bottle x 1 Packet

Generics : Nalidixic Acid

Manufacturer : Square Pharmaceuticals Ltd.

Best Price * TK 41.86

* Delivery will be done in Dhaka city only.

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More Information About - Nalid PFS 50ml 300mg/5ml

Description

Generic Name

Nalidixic Acid

Precaution

Hepatic or moderate renal impairment, severe cerebral arteriosclerosis, G6PD deficiency. Monitor blood counts, renal and hepatic function for treatment >2 wk. Children <18 yr. Elderly. Avoid exposure to sunlight or sunlamps. Pregnancy and lactation.

Indication

Lower urinary tract infections, Shigellosis

Contra Indication

Hypersensitivity. History of convulsive disorders or porphyria. Infants <3 mth. Severe renal impairment.

Dose

N/A

Side Effect

Nausea, vomiting, diarrhoea, abdominal pain; photosensitivity reactions, allergic rash, urticaria, pruritus; visual disturbances, headache, dizziness or vertigo, drowsiness, confusion, depression, excitement, hallucinations, toxic psychoses or convulsions (especially after large doses), intracranial hypertension (especially in infants and young children), metabolic acidosis; peripheral neuropathies, muscular weakness, myalgia; arthralgia, tendon damage; cholestatic jaundice, thrombocytopenia, leucopenia. Potentially Fatal: Erythema multiforme and Stevens-Johnson syndrome; anaphylactoid reactions. Auto-immune haemolytic anaemia (particularly in elderly patients).

Pregnancy Category

Name : C

Description

Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks

Mode of Action

Nalidixic acid is a 4-quinolone antibacterial. It interferes with the replication of bacterial DNA by inhibiting DNA gyrase activity. It acts against gram-negative bacteria including E. coli, Proteus, Klebsiella, Enterobacter, Salmonella and Shigella spp.

Interaction

Absorption reduced by sucralfate, and divalent and trivalent cations e.g. aluminium, calcium, iron, magnesium, zinc. Excretion reduced and plasma concentrations increased with probenecid. Reduced effects with chloramphenicol, nitrofurantoin, tetracycline. Potentially Fatal: Fatal haemorrhagic enterocolitis may occur when used with high-dose melphalan in children. Increased risk of nephrotoxicity with ciclosporin. May increase effects of oral anticoagulants e.g. warfarin.

Pregnancy Category Note

N/A

Adult Dose

Oral Uncomplicated lower urinary tract infections Adult: 1 g 4 times daily for 1-2 wk. Long-term therapy: Reduce daily dose to 2 g. Shigellosis Adult: 1 g 4 times daily for 5 days. Hepatic impairment: Reduced doses should be considered.

Child Dose

Oral Uncomplicated lower urinary tract infections Child: >3 mth: 50 mg/kg daily in 4 equally divided doses. Long-term therapy: Reduce dose to 30 mg/kg daily. Prophylaxis: 15 mg/kg bid. Shigellosis Child: >3 mth: 15 mg/kg 4 times daily for 5 days.

Renal Dose

Renal impairment: Reduced doses should be considered.

Administration

Should be taken with food.

Disclaimer

The information provided herein are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please note that this information should not be treated as a replacement for physical medical consultation or advice. Great effort has been placed to provide accurate and comprehensive data. However, Medicart along with its authors and editors make no representations or warranties and specifically disclaim all liability for any medical information provided on the site. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company.