Long term treatment with antibiotics may enhance development of secondary fungal infections or may support growth of non-susceptible bacteria. Contact lenses should not be worn in the presence of infectious eye diseases and the product should not be instilled while wearing contact lenses. During prolonged use, it is recommended that physicians conduct periodic examinations of the eye, including measurement of the intraocular pressure.
Lomefloxacin is contraindicated in patients with a history of hypersensitivity to Lomefloxacin, quinolone or any other components of this product.
Dose
N/A
Side Effect
Mild, transient sensation of burning, irritation or pain may be experienced on instillation.
Pregnancy Category
Name :
C
Description
Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks
Mode of Action
Lomefloxacin promotes breakage of double-stranded DNA in susceptible organisms and inhibits DNA gyrase, which is essential in reproduction of bacterial DNA.
Interaction
Reduced bioavailability with sucralfate, antacids containing magnesium or aluminium, vitamin or mineral supplements containing iron. Increased serum levels with cimetidine. Potential increase in serum levels of ciclosporin. Renal elimination reduced with probenecid.
Potentially Fatal: Increased risk of ventricular arrhythmias with class IA (quinidine, procainamide) or class III (amiodarone, sotalol) antiarrhythmic agents.
Pregnancy Category Note
N/A
Adult Dose
Ophthalmic
Bacterial conjunctivitis
Adults
At the beginning of therapy on day 1: Instill 5 drops into the conjunctival sac within 20 minutes.
Thereafter, until day 7-9: Instill 1 drop 3 times daily into the conjunctival sac.
Otic/Aural
Otitis externa
10 drops (0.5 mL, 1.5 mg ofloxacin) instilled into the affected ear once daily for 7 days.
Chronic Suppurative Otitis Media with perforated tympanic membranes:
10 drops (0.5 mL, 1.5 mg ofloxacin) instilled into the affected ear twice daily for 14 days.
Child Dose
Ophthalmic
Bacterial conjunctivitis
Adults
At the beginning of therapy on day 1: Instill 5 drops into the conjunctival sac within 20 minutes.
Thereafter, until day 7-9: Instill 1 drop 3 times daily into the conjunctival sac.
Otic/Aural
Otitis externa
For patients 13 years and older: 10 drops (0.5 mL, 1.5 mg ofloxacin) instilled into the affected ear once daily for 7 days.
Acute Otitis Media
(1 to 12 years old) with tympanostomy tubes is:
5 drops (0.25 mL, 0.75 mg ofloxacin) instilled into the affected ear twice daily for 10 days.
Chronic Suppurative Otitis Media with perforated tympanic membranes:
12 years and older:
10 drops (0.5 mL, 1.5 mg ofloxacin) instilled into the affected ear twice daily for 14 days.
Renal Dose
N/A
Administration
N/A
Disclaimer
The information provided herein are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please note that this information should not be treated as a replacement for physical medical consultation or advice. Great effort has been placed to provide accurate and comprehensive data. However, Medicart along with its authors and editors make no representations or warranties and specifically disclaim all liability for any medical information provided on the site. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company.