Generic Name

Triamcinolone Acetonide Mouth prep

Precaution

Diabetes; hypertension, renal and liver impairment; glaucoma; psychosis; delayed tissue healing; cirrhosis; heart failure; recent MI; hypothyroidism; osteoporosis; peptic ulceration; thromboembolic disorders. Monitor height in children on prolonged therapy. Avoid rapid drug withdrawal. Elderly, children, pregnancy, lactation.

Indication

Mouth ulceration

Contra Indication

Untreated systemic fungal, bacterial, viral or parasitic infection, hypersensitivity.

Dose

N/A

Side Effect

Local burning, itching, irritation, GI upsets; increased fragility of mucosa of the mouth.

Pregnancy Category

Mode of Action

Triamcinolone has mainly glucocorticoid activity. It suppresses the migration of polymorphonuclear leukocytes and reduces capillary permeability thereby decreasing inflammation.

Interaction

Lowering of plasma salicylates levels. Increased risk of GI bleeding and ulceration with NSAIDs. Antagonised blood glucose-lowering effects of the antidiabetics. Increased risk of hyperkalaemia with amphotericin B, beta agonists, beta-blockers, potassium-depleting diuretics, theophylline. Increased clearance of the triamcinolone with ciclosporin, carbamazepine, phenytoin, barbiturate, rifampicin. Infections may develop if given with live vaccines.

Pregnancy Category Note

N/A

Adult Dose

Mouth/Throat Mouth ulceration Adult: A small amount (about 0.6 cm) of the 0.1% paste is pressed onto the lesion without rubbing until a thin film develops. Apply 2 or 3 times daily, preferably after meals. Re-evaluate if recovery does not occur after 7 days of treatment.

Child Dose

N/A

Renal Dose

N/A

Administration

N/A