Generic Name

Ketotifen

Precaution

May impair tasks requring mental alertness e.g. driving or operating machinery. History of epilepsy. Pregnancy and lactation. Children <3 yr. Lactation: secreted into breast milk, do not use if breastfeeding

Indication

Allergic conjunctivitis, Allergic conditions, Asthma prophylaxis

Contra Indication

Acute asthma attack.

Dose

N/A

Side Effect

1-10% Weight gain (5.3%),Rash (4%),Respiratory infection (4%),Abdominal pain (1.3%),Increased appetite (1.3%),Epistaxis (1.3%),Puffy eyelid (1.3%),Sleep disturbance (1.3%)

Pregnancy Category

Mode of Action

Ketotifen selectively and noncompetitively inhibits the release of mediators from cells involved in hypersensitivity reactions. It is also a mast cell stabiliser.

Interaction

Reduced platelet count with oral antidiabetics. Potentially Fatal: May potentiate CNS effects of sedatives, hypnotics, antihistamines and alcohol.

Pregnancy Category Note

Pregnancy Category: safety not established; weigh risk/benefit Lactation: secreted into breast milk, do not use if breastfeeding

Adult Dose

Oral Allergic conditions; Asthma prophylaxis Adult: 1 mg bid up to 2 mg bid, as needed. Alternatively, 0.5-1 mg at night for the 1st few days of treatment to minimise drowsiness.

Child Dose

Allergic conditions; Asthma prophylaxis Tablet Child: 6 mth to 3 yr: 0.5 mg bid; >3 yr: 1 mg bid. Syrup: 6 months to 3 years: 0.25 ml / kg body weight, twice daily (Once in the morning & once in the evening).

Renal Dose

N/A

Administration

Should be taken with food.