This sterile Eye Suspension is used to treat steroid-responsive inflammatory ocular diseases in which a corticosteroid is prescribed yet there is a risk of bacterial eye infection.
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Tobramycin's bactericidal activity is achieved, like that of other amino-glycosides, by inhibiting normal protein synthesis in susceptible bacteria, but nothing is understood about how this action works at the moment. Protein synthesis suppression is hypothesized to be caused by a ribosome activity that causes bacterial messenger RNA misreading. Dexamethasone works by inhibiting phospholipase A2, which is the first step in prostaglandin formation. Dexamethasone also prevents neutrophils from chemo-tactically infiltrating the inflammatory site.As a result, it has a 25-fold higher anti-inflammatory activity and an 8-10-fold higher overall therapeutic effectiveness than hydrocortisone.
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This combination eye drop has not been subjected to any particular interaction studies. In the case of simultaneous therapy with other topical ophthalmic drugs, a 10-minute delay between applications should be given.
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Localized ocular toxicity and hypersensitivity, including lid irritation and swelling, as well as conjuntival erythema, are the most common side effects of topical ocular Tobramycin. The steroid component causes an increase in intraocular pressure (IOP), which can lead to glaucoma and infrequent optic nerve injury, as well as the production of posterior subcapsule cataracts.
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It has not been determined whether or not it is safe to use during pregnancy and lactation in humans.
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Before using, give the bottle a good shake. To avoid contamination, avoid touching the bottle's tip to the affected eye, eyelid, or any other surface of the affected eye. After each usage, carefully shut the bottle.
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Allow to cool to room temperature before using. After each usage, immediately close the bottle. After opening the bottle, do not use it for more than one month.
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