Generic Name

Acemetacin

Precaution

Elderly; allergic disorders/coagulation defects; epilepsy; parkinsonism; psychiatric disturbances (prolonged therapy may require ophthalmic and blood examinations); renal, hepatic or cardiac impairment.

Indication

Rheumatoid arthritis, Osteoarthritis, Lower back pain, Ankylosing spondylitis, Post-operative pain, Musculoskeletal and joint pain

Contra Indication

Previous/active peptic ulcers; hypersensivity to aspirin/NSAIDs; severe liver disease; neonates with untreated infection, children, pregnancy, lactation.

Dose

N/A

Side Effect

Headaches, dizziness, GI disturbances; anaemia; acute interstitial nephritis; corneal deposits, retinal disturbances; rash, urticaria; alopoecia; CHF, tachycardia, arrhythmias, palpitations; jaundice. Potentially Fatal: Toxic hepatitis, Stevens-Johnson syndrome.

Pregnancy Category

Mode of Action

Acemetacin is the glycolic acid ester of indometacin. It inhibits cyclooxygenase and hence prevents the formation of prostaglandins which are involved in the inflammation process.

Interaction

May reduce the antihypertensive effect of beta-blockers. May prolong bleeding when used with acenocoumarol. Increased risk of convulsion when used with quinolone. Concurrent use with aspirin, NSAIDs, SSRIs or corticosteroids may increase risk of GI bleeding. May increase serum levels of ciclosporin. May increase serum levels of lithium. Potentially Fatal: Increased risk of methotrexate toxicity when used together.

Pregnancy Category Note

N/A

Adult Dose

Adult: PO Pain and inflammation associated with musculoskeletal and joint disorders; Post-op pain 120-180 mg/day.

Child Dose

N/A

Renal Dose

N/A

Administration

Should be taken with food. Take w/ or immediately after meals.