Ebastine
Caution is advised when used in hepatic impairment, renal insufficiency, QTc interval prolongation. Pregnancy, lactation.
Allergic rhinitis, Allergic conditions, Chronic idiopathic urticaria
Hypersensitivity, cardiac arrhythmias.
N/A
Headache, dry mouth, drowsiness, pharyngitis, abdominal pain, dyspepsia, asthenia, epistaxis, rhinitis, sinusitis, nausea, insomnia.
Ebastine, a piperidine derivative, is a long-acting, nonsedating, second-generation histamine receptor antagonist that binds preferentially to peripheral H1 receptors. It is metabolised to active metabolite, carebastine. It has antihistaminic, antiallergic activity and prevents histamine-induced bronchoconstriction. It does not have significant sedative or antimuscarinic actions.
Concomitant use of ketoconazole, itraconazole, clarithromycin or erythromycin may increase plasma levels of ebastine and cause QTc interval prolongation.
N/A
Oral Allergic conditions Adult: 10-20 mg once daily.
Oral Allergic conditions Child: >6 yr: 5 mg once daily.
N/A
May be taken with or without food.
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