Indications:

The following conditions are treated with aspirin. - Prophylaxis against occlusive events of the arteries: Acute ischemic stroke/TIA, myocardial infarction, myocardial re-infarction, following bypass surgery

• Headache, muscle discomfort, dysmenorrhoea, and toothache are examples of mild to moderate pain.
• Chronic pain and inflammation are common symptoms of chronic illness. Osteoarthritis.
• Cold fever and influenza are antipyretics.

Dosage (breakdown or, not) :

Administration:

Alcohol, corticosteroids, analgin, phenylbutazone and oxyphenbutazone may increase risk of GI ulceration. Aspirin increases phenytoin levels. May antagonize actions of uricosurics and spironolactone. Potentially Fatal: May potentiate effects of anticoagulants, methotrexate and oral hypoglycaemics.

Interaction:

Hypersensitivity (attacks of asthma, angioedema, urticaria or rhinitis), active peptic ulceration; pregnancy (3rd trimester), children <12 yr, patients with haemophilia or haemorrhagic disorders, gout, severe renal or hepatic impairment, lactation.

Contraindication:

PO Juvenile rheumatoid arthritis Child: <25 kg: 60-100 mg/kg/day PO divided q6-8hr (maintain serum salicylate at 150-300 mcg/mL) >25 kg: 2.4-3.6 g/day Pain & Fever <12 years 10-15 mg/kg PO q4hr, up to 60-80 mg/kg/day

Side Effect:

Renal impairment CrCl >10 mL/min: Dose adjustment not necessary CrCl <10 mL/min: Not recommended

Pregnancy:

GI disturbances; prolonged bleeding time, rhinitis, urticaria and epigastric discomfort; angioedema, salicylism, tinnitus; bronchospasm. Potentially Fatal: Gastric erosion, ulceration and bleeding; severe, occasionally fatal exacerbation of airway obstruction in asthma; Reye's syndrome (children <12 yr). Hepatotoxicity; CNS depression which may lead to coma; CV collapse and resp failure; paroxysmal bronchospasm and dyspnoea.