History of hypersensitivity or toxic reaction to the drug; Perforated ear drum. Herpes simplex and other viral conditions of the eye or ear, mycosis.
Dose
N/A
Side Effect
Ophthalmic application: Hypersensitivity reactions including rashes, fever and angioedema.
Ear drops: Ototoxicity.
Pregnancy Category
Name :
C
Description
Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks
Mode of Action
Dexamethasone is a synthetic glucocorticoid which decreases inflammation by inhibiting the migration of leukocytes and reversal of increased capillary permeability. It suppresses normal immune response.
Chloramphenicol inhibits bacterial protein synthesis by binding to 50s subunit of the bacterial ribosome, thus preventing peptide bond formation by peptidyl transferase.
Interaction
Decreased effects of iron and vitamin B12 in anaemic patients. Phenobarbitone and rifampin reduce efficacy of chloramphenicol. Impairs the action of oral contraceptives.
Pregnancy Category Note
N/A
Adult Dose
Ocular infections Adult: Instill 1 drop of asolution every 2 hr. Increase dosage interval upon improvement. To continue treatment for at least 48 hr after complete healing.
Otic/Aural Otitis externa Adult: Instill 2-3 drops into the ear bid-tid.
Child Dose
N/A
Renal Dose
N/A
Administration
N/A
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