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Megestol - 160 mg
Tablet
Pack Size :
8 Tablet x 1 Strip
Generics :
Megestrol Acetate
Manufacturer :
Ziska Pharmaceuticals Ltd.
Best Price *
TK
640.00
* Delivery will be done in Dhaka city only.
Alternative Product
More Information About - Megestol - 160 mg
Description
Generic Name
Megestrol AcetatePrecaution
History of thrombophlebitis, mild to moderate hepatic impairment, risk of fluid retention, history of depression, diabetes, hypertension, renal or cardiac dysfunction. Lactation: Not safe; do not nurseIndication
Breast carcinoma, Endometrial carcinoma, Anorexia and Cachexia aids and cancer relatedContra Indication
Pregnancy and lactation. Severe hepatic impairment.Dose
N/ASide Effect
Common Hypertension,Insomnia, mood swings Rash, sweating,Amenorrhea, breakthrough bleeding, change in menstrual flow, hot sweats, impotence, spotting Diarrhea, flatulence, indigestion, nausea, vomiting, weight gain Serious Deep vein thrombosis (DVT),Pulmonary embolism,Thrombophlebitis,Anemia,Adrenal insufficiencyPregnancy Category
Name : Not Classified
Description
FDA has not yet classified the drug into a specified pregnancy category.Mode of Action
Megestrol is a progestogen used as an antineplastic and appetite stimulant. The mechanism of it's antineoplastic effects is not known but may be due to inhibition of oestrogen synthesis, modulation of other steroid hormones and/or a direct cytotoxic effect on tumour cells.Interaction
Concentrations of indinavir may be reduced. Possible reduced efficacy of cisplatin. Warfarin half life may be increased. Megestrol concentration may be decreased by aminoglutethimide and enzyme-inducing drugs.Pregnancy Category Note
Pregnancy Obtain a pregnancy test in females of reproductive potential prior to initiating treatment; advise females of reproductive potential to use effective contraception while taking drug There are no available human data to assess for any drug-associated risks of miscarriage, birth defects, or adverse maternal or fetal outcomes; advise a pregnant women of potential risk to fetus Pregnancy testing is recommended prior to treatment Contraception Therapy may cause fetal harm when administered during pregnancy; advise females of reproductive potential to use effective contraception during treatment Animal data Based on animal data, megestrol acetate may cause fetal harm when administered to a pregnant woman and is contraindicated during pregnancy; there are no adequate animal developmental toxicity data at clinically relevant doses; pregnant rats treated with low doses resulted in reduction in fetal weight and number of live births, and feminization of male fetuses at doses below maximum recommended clinical dosing based on body surface area Lactation The Centers for Disease Control and Prevention recommend that HIV-1 infected mothers not breastfeed their infants to avoid risking postnatal transmission of HIV-1; the drug is present in human milk; there are no data on effects of drug on breastfed infant or on milk production; because of potential for HIV transmission and adverse effects on a breastfed infant, instruct mothers not to breastfeed if they are receiving therapyAdult Dose
Oral Palliative treatment of breast carcinoma Adult: 40 mg 4 times daily or 160 mg once daily. Palliative treatment of endometrial carcinoma Adult: 40-320 mg daily in divided doses. evaluate efficacy after 2 months of treatment; up to 800 mg/day may be used Anorexia and cachexia in patients with cancer or AIDS Adult: Initial: 800 mg daily. Usual range: 400-800 mg daily.Child Dose
N/ARenal Dose
Renal impairment: Use with caution; in normal renal function, 57-78% is excreted in urine within 10 daysAdministration
Should be taken with food.Disclaimer
The information provided herein are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please note that this information should not be treated as a replacement for physical medical consultation or advice. Great effort has been placed to provide accurate and comprehensive data. However, Medicart along with its authors and editors make no representations or warranties and specifically disclaim all liability for any medical information provided on the site. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company.
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