Peptid - 20 mg

Tablet

Pack Size : 14 Tablet x 1 Strip

Generics : Famotidine

Manufacturer : Opsonin Pharma Ltd.

Best Price * TK 28.00

* Delivery will be done in Dhaka city only.

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More Information About - Peptid - 20 mg

Description

Generic Name

Ranitidine

Precaution

Possibility of malignancy should be excluded prior to therapy as the drug may mask symptoms and delay diagnosis of gastric malignancy. Patients w/ difficulty in swallowing. Renal and hepatic impairment. Pregnancy and lactation. Lactation: Drug crosses into breast milk; discontinue drug, use caution

Indication

Dyspepsia, H. pylori infection, Benign gastric and duodenal ulceration, GERD, Acid aspiration during general anesth, Prophylaxis during NSAID treatment, Stress ulceration of upper GI, Zollinger-Ellison syndrome

Contra Indication

Porphyria.

Dose

N/A

Side Effect

1-10% Headache (3%) <1% Abdominal pain,Agitation,Alopecia,Confusion,Constipation,Diarrhea,Dizziness,Hypersensitivity reaction,Nausea,Vomiting Frequency Not Defined Anemia,Necrotizing enterocolitis in fetus or newborn,Pancreatitis (rare),Thrombocytopenia (rare),Pancytopenia (rare),Agranulocytosis (rare),Acquired immune hemolytic anemia (rare),Arthralgia (rare),Myalgia (rare) Potentially Fatal: Anaphylaxis, hypersensitivity reactions.

Pregnancy Category

Name : B

Description

Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.

Mode of Action

Ranitidine competitively blocks histamine at H2-receptors of the gastric parietal cells which inhibits gastric acid secretion. It does not affect pepsin secretion, pentagastrin-stimulated intrinsic factor secretion or serum gastrin.

Interaction

Delayed absorption and increased peak serum concentration w/ propantheline bromide. Ranitidine minimally inhibits hepatic metabolism of coumarin anticoagulants, theophylline, diazepam and propanolol. May alter absorption of pH-dependent drugs (e.g. ketoconazole, midazolam, glipizide). May reduce bioavailability w/ antacids.

Pregnancy Category Note

Pregnancy category: B Lactation: Drug crosses into breast milk; discontinue drug, use caution

Adult Dose

Oral Benign gastric and duodenal ulceration Adult: Initially, 300 mg daily at bedtime or 150 mg bid for 4-8 wk; 300 mg bid for 4 wk may be used in duodenal ulcer to improved healing. Maintenance: 150 mg daily at bedtime. Max: 300 mg bid. Hypersecretory conditions Adult: Initially, 150 mg bid or tid and increased if needed. Max: 6 g daily. Gastro-oesophageal reflux disease Adult: 150 mg bid or 300 mg at bedtime for up to 8 wk, may increase to 150 mg 4 times daily for 12 wk in severe cases. Dyspepsia Adult: Chronic episodic: 150 mg bid for up to 6 wk. Short-term symptomatic relief: 75 mg repeated if necessary up to 4 doses daily. Max duration: 2 wk of continuous use at one time. Erosive oesophagitis Adult: 150 mg 4 times daily. Maintenance: 150 mg bid. NSAID-associated ulceration Adult: 150 mg bid or 300 mg at bedtime for 8-12 wk. For prevention of NSAID-associated ulceration: 150 mg bid. Hepatic impairment: Dosage adjustment not necessary

Child Dose

Oral Benign gastric and duodenal ulceration Child: 1 mth to 16 yr 4-8 mg/kg daily in 2 divided doses. Max: 300 mg/day. Treatment duration: 4-8 wk. Maintenance: 2-4 mg/kg once daily. Max: 150 mg/day. Gastro-oesophageal reflux disease Child: 1 mth to 16 yr 5-10 mg/kg daily in 2 divided doses. Max: 300 mg/day. Erosive oesophagitis Child: 1 mth to 16 yr 5-10 mg/kg daily in 2 divided doses. Max: 600 mg/day.

Renal Dose

Oral: CrCl Dosage <50 150 mg daily at bedtime, adjust dose cautiously if necessary.Parenteral: Individual doses may be reduced to 25 mg.

Administration

May be taken with or without food. IV Administration Direct injection: 50 mg diluted to ?20 mL with compatible IV infusion fluid and given over ?5 minutes (4 mL/min) Intermittent infusion: 50 mg added to ?100 mL of compatible IV solution and infused over 15-20 minutes Continuous infusion: 150 mg diluted in 250 mL of IV fluid and infused at 6.25 mg/hr for 24 hours

Disclaimer

The information provided herein are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please note that this information should not be treated as a replacement for physical medical consultation or advice. Great effort has been placed to provide accurate and comprehensive data. However, Medicart along with its authors and editors make no representations or warranties and specifically disclaim all liability for any medical information provided on the site. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company.