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PTU - 50 mg
Tablet
Pack Size :
14 Tablet x 1 Strip
Generics :
Renata Limited
Manufacturer :
Renata Limited
Best Price *
TK
140.00
* Delivery will be done in Dhaka city only.
More Information About - PTU - 50 mg
Description
Generic Name
PropylthiouracilPrecaution
Reserve use for patients unable to tolerate any other treatments e.g. methimazole, radioactive iodine or surgery. Inform patient of liver failure risk and to report any signs of liver dysfunction (e.g. loss of appetite, nausea, vomiting, pruritus, dark coloured urine, light coloured stools, jaundice, right upper-quadrant pain) or agranulocytosis (e.g. fever, sore throat) immediately. Stop treatment upon signs of agranulocytosis, aplastic anaemia, fever, liver injury, elevated LFT above 3 times the upper limit of normal, or exfoliative dermatitis. Regular monitoring of thyroid function and CBC is advisable. Monitor prothrombin time regularly during treatment, especially before surgical procedures. Lactation: distributed in breast milk, contraindicated by some sources (AAP Committee states compatible w/ nursing ; AAFP states safe for nursing)Indication
HyperthyroidismContra Indication
Hypersensitivity, pregnancy, lactation.Dose
N/ASide Effect
Mild leukopenia, lupus-like syndrome, cutaneous vasculitis, thrombocytopenia. Skin rash, urticaria, arthralgia and fever. GI discomfort, vomiting, headache. Potentially Fatal: Agranulocytosis, aplastic anaemia, liver injury and liver failure.Pregnancy Category
Name : D
Description
There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.Mode of Action
Propylthiouracil inhibits the production of thyroid hormones by preventing iodine from being oxidised in the thyroid gland. It also blocks the peripheral deiodination of thyroxine to tri-iodothyronine.Interaction
May potentiate activity of anticoagulants. Doses of ?-blockers, digitalis glycosides and theophylline may need to be reduced when patient becomes euthyroid.Pregnancy Category Note
Pregnancy Category: D Lactation: distributed in breast milk, contraindicated by some sources (AAP Committee states compatible w/ nursing ; AAFP states safe for nursing)Adult Dose
Oral Hyperthyroidism Adult: 150-450 mg daily in divided doses. For severe cases, initial doses of 600-1200 mg daily have been used. Maintenance dose for euthyroid patients: 50-150 mg daily. Treatment is usually continued for 1-2 yr. Hepatic impairment: Dose reduction is recommended.Child Dose
Oral Hyperthyroidism Child: Neonates: 2.5-5 mg/kg bid; 1 mth-1 yr: 2.5 mg/kg tid; 1-5 yr: 25 mg tid; 5-12 yr: 50 mg tid; 12-18 yr: 100 mg tid.Renal Dose
Renal impairment: CrCl (ml/min) Dosage Recommendation <10 Reduce dose by 50%. 10-50 Reduce dose by 25%.Administration
Should be taken with food.Disclaimer
The information provided herein are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please note that this information should not be treated as a replacement for physical medical consultation or advice. Great effort has been placed to provide accurate and comprehensive data. However, Medicart along with its authors and editors make no representations or warranties and specifically disclaim all liability for any medical information provided on the site. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company.
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