Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks
Mode of Action
Fexofenadine, an active metabolite of terfenadine, is a competitive peripheral histamine H1-receptor antagonist on effector cells in the GI tract, blood vessels and respiratory tract.
Interaction
Co-admin with ketoconazole or erythromycin may increase plasma levels of fexofenadine. May increase adverse effects of other anticholinergics and CNS depressants. May increase arrhythmogenic effect of antipsychotic agents (phenothiazines); avoid concurrent usage. May reduce the efficacy of betahistine. Pramlintide may increase the anticholinergic effect of fexofenadine. Bioavailability may be increased by verapamil. Efficacy may be reduced by rifampin.
Pregnancy Category Note
Pregnancy category: C
Lactation: Excretion in milk unknown; use with caution (AAP states ?compatible with nursing?)
Adult Dose
Adults:
Seasonal Allergic Rhinitis/Chronic Idiopathic Urticaria
60 mg twice daily or 120 mg once daily or 180 mg once daily with water
Child Dose
Children:
Seasonal Allergic Rhinitis
<2 years: Use not recommended
2-12 years: 30 mg PO BID or 5 ml twice daily
>12 years: 60 mg PO BID OR 180 mg PO qDay
ODT
6-12 years: 30 mg PO BID
Chronic Idiopathic Urticaria
<6 months: Use not recommended
6 months-2 years: 15 mg PO BID or 2.5 ml twice daily
2-12 years: 30 mg PO BID
>12 years: 60 mg PO BID OR 180 mg PO qDay
ODT
6-12 years: 30 mg PO BID
Renal Dose
Renal impairment (CrCl <80 mL/min): 60 mg PO qDay initially
Administration
Should be taken on an empty stomach. Take before meals. Take with water. Do not take w/ fruit juice.
ODT: Allow to disintegrate on tongue, followed by swallowing with or without water;
Disclaimer
The information provided herein are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please note that this information should not be treated as a replacement for physical medical consultation or advice. Great effort has been placed to provide accurate and comprehensive data. However, Medicart along with its authors and editors make no representations or warranties and specifically disclaim all liability for any medical information provided on the site. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company.