All Products
Men Care
Women Care
Sexual Wellness
Herbal & Homeopathy
Baby & Mom Care
Personal Care
Aparkin - 50mg
Capsule
Pack Size :
10 Capsule x 1 Strip
Generics :
Levodopa + Benserazide
Manufacturer :
Ziska Pharmaceuticals Ltd.
Best Price *
TK
80.00
* Delivery will be done in Dhaka city only.
Alternative Product
More Information About - Aparkin - 50mg
Description
Generic Name
Levodopa + BenserazidePrecaution
CV disease, liver or renal disease, pulmonary disease, endocrine disorders, seizure disorders, psychiatric disturbances (e.g. depression); open-angle glaucoma, osteomalacia, history of peptic ulcer. Monitor hepatic, psychiatric, haematological, renal and CV functions periodically. Levodopa has been associated with somnolence and sudden onset of sleep; patients should not drive or operate machine if experienced such effects. Neuroleptic malignant-like syndrome has been reported on abrupt withdrawal. Long term use of Levodopa and/or dopamine agonists has been associated with behavioural disturbances such as hypersexuality, excessive gambling or shopping, punding.Indication
Parkinson's diseaseContra Indication
Concurrent use or within 2 wk of withdrawal of non-selective monoamine oxidase (MAO) inhibitors. Severe psychoneuroses or psychoses; severe endocrine, renal, hepatic or cardiac disorders; narrow-angle glaucoma; malignant melanoma; in patients < 25 yr, and pregnancy.Dose
Adult: PO Parkinson's disease As standard forms or dispersible forms in Levodopa (mg)/Benserazide (mg) 50/12.5, 100/25, 200/50. Doses expressed as Levodopa: Initially 50 mg 3-4 times/day (100 mg 3 times/day in advance stage disease); increase by 100 mg/day once or twice wkly. Effective dose range: 400-800 mg/day in divided doses. Patients previously on levodopa monotherapy: Initiate with 10-15% of the usual dose previously taken. Patient previously on other levodopa/dopa-decarboxylase combination therapy: Withdraw previous therapy for 12 hr before initiating therapy at 50 mg 3-4 times/day. As controlled release cap of Levodopa 100 mg/Benserazide 25 mg: Initially 1 cap 3 times/day; max initial dose: 6 caps/day. Patients previously on immediate-release Levodopa/Benserazide preparations: Initial dose should substitute every 100 mg of Levodopa with 1 controlled-release cap, given at same dosage frequency as before. Increase every 2-3 days according to response.Side Effect
GI disturbances e.g. nausea, vomiting, anorexia, diarrhoea, taste disturbances. GI bleeding in peptic ulcer patients. Orthostatic hypotension, cardiac arrhythmias. Psychiatric disturbances e.g. mild elation, anxiety, agitation, insomnia, drowsiness, depression, aggression, hallucination. Somnolence, sudden onset of sleep episodes. Abnormal involuntary movements e.g. dyskinesia, dystonia, chorea. Haemolytic anemia, transient leucopenia and thrombocytopenia. Transient elevations of liver enzymes; increased BUN and uric acid.Pregnancy Category
Name : Not Classified
Description
FDA has not yet classified the drug into a specified pregnancy category.Mode of Action
Levodopa is the metabolic precursor of dopamine. Only a small amount of administered Levodopa enters blood-brain barrier unaltered and the remainder is converted peripherally to dopamine by dopa-decarboxylase. Benserazide is a peripheral decarboxylase inhibitor that reduces the peripheral conversion of Levodopa; concurrent admin enables dosage of Levodopa to be reduced and may diminish peripheral side effects such as nausea and vomiting.Interaction
Increased postural hypotension and possible reduced absorption of Levodopa with TCAs. Reduced effects with phenothiazines, butyrophenones, thioxanthenes and other antipsychotic agents; reserpine, papaverine, phenytoin and isoniazid. Reduced absorption with ferrous sulphate. Pyridoxine (10-25 mg) may reverse antiparkinsonian effect of Levodopa in the absence of concurrent dopa-decarboxylase inhibitor. Exacerbation of abnormal involuntary movements and possibly delayed absorption when used with anticholinergics. Additive hypotensive effects with antihypertensive agents. Increased CNS toxicity with methyldopa. Exacerbation of parkinsonian symptoms with metoclopramide due to its antagonistic effects on dopamine receptor.Pregnancy Category Note
Should not be used in women of child-bearing potential without adequate contraception. Breast-feeding is not recommended.Adult Dose
Adult: PO Parkinson's disease As standard forms or dispersible forms in Levodopa (mg)/Benserazide (mg) 50/12.5, 100/25, 200/50. Doses expressed as Levodopa: Initially 50 mg 3-4 times/day (100 mg 3 times/day in advance stage disease); increase by 100 mg/day once or twice wkly. Effective dose range: 400-800 mg/day in divided doses. Patients previously on levodopa monotherapy: Initiate with 10-15% of the usual dose previously taken. Patient previously on other levodopa/dopa-decarboxylase combination therapy: Withdraw previous therapy for 12 hr before initiating therapy at 50 mg 3-4 times/day. As controlled release cap of Levodopa 100 mg/Benserazide 25 mg: Initially 1 cap 3 times/day; max initial dose: 6 caps/day. Patients previously on immediate-release Levodopa/Benserazide preparations: Initial dose should substitute every 100 mg of Levodopa with 1 controlled-release cap, given at same dosage frequency as before. Increase every 2-3 days according to response.Child Dose
N/ARenal Dose
N/AAdministration
Standard cap & HBS cap: Should be taken on an empty stomach. Best taken at least 30 min before or 1 hr after meals, whenever possible. GI discomfort which occurs mainly in the early stages of treatment may be controlled by taking w/ food or liqd or by increasing the dose slowly. Swallow whole, do not chew/crush. Dispersible tab: Should be taken on an empty stomach. Best taken at least 1 hr before or 1 hr after meals, whenever possible. GI discomfort which occurs mainly in the early stages of treatment may be controlled by taking w/ food or liqd or by increasing the dose slowly. Disperse in ? glass of water (approx 25-50 mL). Stir before drinking. Consume entire amount w/in ? hr of dissolving the tab.Disclaimer
The information provided herein are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please note that this information should not be treated as a replacement for physical medical consultation or advice. Great effort has been placed to provide accurate and comprehensive data. However, Medicart along with its authors and editors make no representations or warranties and specifically disclaim all liability for any medical information provided on the site. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company.
Others Product
In Stock
In Stock
Prescribed
In Stock
In Stock
