Quinivir 200 - 200mg

Tablet

Pack Size : 10 Tablet x 1 Strip

Generics : Hydroxychloroquine Sulphate

Manufacturer : Square Pharmaceuticals Ltd.

Best Price * TK 120.00

* Delivery will be done in Dhaka city only.

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More Information About - Quinivir 200 - 200mg

Description

Generic Name

Hydroxychloroquine Sulphate

Precaution

Impaired liver or renal function, severe GI disorders, porphyria, psoriasis, neurological disorders especially a history of epilepsy, myasthenia gravis, G6PD deficiency, pregnancy, lactation. Monitor CBC in patients receiving prolonged therapy. Perform baseline and periodic 6-mth eye exams, test periodically for muscle weakness. Lactation: Drug is concentrated in breast milk (American Academy of Pediatrics committee states that it is compatible with nursing)

Indication

Acute and chronic rheumatoid arthritis, Systemic Lupus Erythematosus (SLE), Malaria

Contra Indication

The presence of retinal or visual field changes attributable to any 4-aminoquinoline compound, patients with known hypersensitivity to 4-aminoquinoline compounds, long term therapy in children.

Dose

N/A

Side Effect

Retinopathy, hair loss, photosensitivity, tinnitus, myopathy (long-term therapy). Psychosis, seizures, leucopenia and rarely aplastic anaemia, hepatitis, GI upsets, dizziness, hypokalaemia, headache, pruritus, urticaria, difficulty in visual accommodation. Loss of hair, bleaching of hair pigment, bluish-black pigmentation of the mucous membranes and skin, photosensitivity, tinnitus, reduced hearing, nerve deafness, neuromyopathy, and myopathy, including cardiomyopathy.

Pregnancy Category

Name : C

Description

Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks

Mode of Action

Hydroxychloroquine is a 4-aminoquinoline antimalarial with actions similar to those of chloroquine but is mainly used in the treatment of SLE and rheumatoid arthritis. It interferes with digestive vacuole function within susceptible malarial parasites by increasing pH and interrupting with lysosomal degradation of Hb thus impeding normal cell function of sensitive parasites.

Interaction

Cimetidine may increase serum levels of hydroxychloroquine. Its absorption may be decreased by kaolin or Mg trisilicate. Avoid digoxin and alcohol. Increased risk of ventricular arrhythmias when used with halofantrine. Concurrent use with mefloquine may increase the risk of convulsions.

Pregnancy Category Note

N/A

Adult Dose

Oral Malaria Acute treatment 800 mg PO, then 400 mg PO 6-8 hours later, then 400 mg PO at 24 and 48 hours Prophylaxis 400 mg PO weekly, starting 2 weeks before exposure and continued for 4 weeks after departure from area Rheumatoid Arthritis 400-600 mg PO daily for 4-12 weeks; maintenance: 200-400 mg PO daily Systemic Lupus Erythematosus 400 mg PO once or twice daily; maintenance: 200-400 mg PO daily Hepatic impairment: Estimation of plasma hydroxychloroquine levels to be undertaken in patients with severely compromised function and dosage adjusted accordingly.

Child Dose

Malaria Acute treatment 13 mg/kg base PO, then 6.5 mg/kg base PO 6 hr later, then 6.5 mg/kg base PO at 24 and 48 hours; not to exceed 400 mg/day base Prophylaxis 6.5 mg/kg base (not to exceed 400 mg [310 mg base]) PO weekly, starting 2 weeks before exposure and continued for 4 weeks after departure from area

Renal Dose

Renal impairment: Estimation of plasma hydroxychloroquine levels to be undertaken in patients with severely compromised function and dosage adjusted accordingly.

Administration

Should be taken with food.

Disclaimer

The information provided herein are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please note that this information should not be treated as a replacement for physical medical consultation or advice. Great effort has been placed to provide accurate and comprehensive data. However, Medicart along with its authors and editors make no representations or warranties and specifically disclaim all liability for any medical information provided on the site. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company.