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Combicid - 15mg
Cream
Pack Size :
1 Tube x 1 Packet
Generics :
Clobetasol Propionate
Manufacturer :
Square Pharmaceuticals Ltd.
Best Price *
TK
150.00
* Delivery will be done in Dhaka city only.
More Information About - Combicid - 15mg
Description
Generic Name
Clobetasol + Ofloxacin + Ornidazole + Terbinafine topicalPrecaution
Should not be used on the face. Do not use the medication for longer periods of time. It contains clobetasol which when used in higher doses and for longer periods can cause a change in the skin color, at the site of the application. Veins beneath the skin become visible because of thinning and weakening of the skin. There could be an increased hair growth. The medicine may get absorbed into the blood and can cause weight gain, high blood pressure and rounding of the face.Indication
Used in the treatment of, skin infections, Corticosteroid-responsive DermatosesContra Indication
HypersensitivityDose
N/ASide Effect
Application site reactions (burning, irritation, itching and redness), Thinning of skin, Skin peelingPregnancy Category
Name : Not Classified
Description
FDA has not yet classified the drug into a specified pregnancy category.Mode of Action
This is a combination of four medicines: Terbinafine, Clobetasol, Ofloxacin and Ornidazole, which treats skin infections. Terbinafine is a allylamine derivative that has a wide spectrum of antifungal activity against pathogens of the skin, hair, and nails. It acts by inhibiting squalene epoxidase, the main enzyme responsible for fungal sterol synthesis. Thus, resulting to ergosterol deficiency, leading to membrane disruption and cell death. It is active against dermatophytes, moulds, and certain dimorphic fungi. Clobetasol is a very potent corticosteroid used in short-term treatment of various inflammatory skin conditions. Corticosteroids decrease inflammation by stabilizing leukocyte lysosomal membranes, preventing release of destructive acid hydrolases from leukocytes; inhibiting macrophage accumulation in inflamed areas; reducing leukocyte adhesion to capillary endothelium; reducing capillary wall permeability and edema formation; decreasing complement components; antagonizing histamine activity and release of kinin from substrates; and reducing fibroblast proliferation, collagen deposition, and subsequent scar tissue formation. Ofloxacin is a fluoroquinolone which inhibits bacterial topoisomerase IV and DNA gyrase enzymes required for DNA replication, transcription, repair, transposition and recombination. It has antibacterial activity against a wide range of gm-ve and gm-+ve microorganisms. Ornidazole is a 5-nitroimidazole derivative active against protozoa and anaerobic bacteria. It is converted to reduction products that interact with DNA to cause destruction of helical DNA structure and strand leading to a protein synthesis inhibition and cell death in susceptible organisms.Interaction
N/APregnancy Category Note
N/AAdult Dose
Adult Topical Corticosteroid-responsive Dermatoses Cream: Apply thin layer to affected areas q12hr and rub in gently and completelyChild Dose
N/ARenal Dose
N/AAdministration
N/ADisclaimer
The information provided herein are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please note that this information should not be treated as a replacement for physical medical consultation or advice. Great effort has been placed to provide accurate and comprehensive data. However, Medicart along with its authors and editors make no representations or warranties and specifically disclaim all liability for any medical information provided on the site. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company.
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