Indications:

• Essential hypertension is treated with propranolol.
• Angina pectoris is a type of heart attack.
• Arrhythmia of the heart
• Thyrotoxicosis
• Anxiety
• Migraine prevention, for example.

Pharmacology:

Indever 10 is a medication that blocks B-adrenergic receptors and is commonly used to treat hypertension and angina pectoris. Propranolol antagonizes catecholamines at B-adrenergic receptors, preventing the heart from contracting too quickly or too forcefully and reducing the heart's oxygen consumption.

Propranolol is virtually entirely absorbed from the gastrointestinal tract, but some of it is processed by the liver as soon as it passes into the portal circulation. After oral treatment, the plasma concentration reaches its peak in 1 to 1.5 hours. Propranolol has a plasma half-life of 3 to 6 hours. Propranolol metabolites are eliminated through the urine.

Dosage (breakdown or, not) :

Adult: 

• Hypertension: Initially 80 mg twice daily, may be increased at weekly intervals and then maintenance dose of 160-320 mg daily is recommended.
• Angina pectoris: Initially 40 mg 2-3 times daily and then maintenance dose of 120-240 mg daily is given.
• Thyrotoxicosis: 10-40 mg, 3-4 times daily is given.
• Anxiety: 40 mg once daily, may be increased to three times daily.
• Prophylaxis of migraine: Initially 40 mg 2-3 times daily; then maintenance dose of 80-160 mg daily is recommended.

Child: 

• Neonate: 0.25-0.5 mg/kg 3 times daily, adjusted according to response.
• Child 1 month: 12 years: 0.25-1 mg/kg 3 times daily, maximum dose 5 mg/kg daily in divided dose.
• Child 12-18 years: initially 80 mg twice daily, maintain 160-320 mg daily.

Administration:

Tab: Should be taken on an empty stomach. Take before meals. Cap: May be taken with or without food. Take consistently either always w/ or always w/o meals.

Interaction:

During treatment, patients taking verapamil, salbutamol, Levosalbutamol, ergot alkaloids, lidocain, or phenobarbital should be properly monitored.

Contraindication:

Sinus bradycardia, cardiogenic shock, sick sinus syndrome, Raynaud's syndrome, 2nd and 3rd degree heart block, overt CHF, bronchial asthma, COPD, untreated phaeochromocytoma, Prinzmetal's angina; severe peripheral arterial disease, metabolic acidosis. Concomitant use w/ thioridazine.

Side Effects: 

Cold extremities, lassitude, nausea, dizziness, sleeplessness, paresthesia, and other symptoms have been reported.

Pregnancy: 

Pregnancy category C should not be utilized by women who are pregnant. Human milk contains propranolol, which is eliminated. When administering propranolol to a breastfeeding mother, extreme caution is advised.

Precautions & Warnings: 

In cases of hepatic and renal impairment, pregnancy, and lactation, it should be used with caution.

Storage Conditions:

Store in a cool and dry place, protected from light.