There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Mode of Action
Carbimazole is metabolised to methimazole which is responsible for its antithyroid action. It blocks the production of thyroid hormones by inhibiting thyroid peroxidase.
Interaction
Increased serum levels of theophylline or may develop toxicity. May enhance the effect of anticoagulants.
Potentially Fatal: Increased sensitivity to warfarin in hyperthyroidism and careful control required as patient is rendered euthyroid.
Pregnancy Category Note
N/A
Adult Dose
Oral
Hyperthyroidism, Adjunct to radio-iodine therapy, Grave's disease, Preparation for thyroidectomy
Adult: Initially, 20-60 mg daily as a single or divided dose, reduced gradually once euthyroidism is achieved. Maintenance: 5-15 mg daily for at least 1 yr or 18 mth.
Hepatic impairment: Severe: Contraindicated.
Child Dose
Oral
Hyperthyroidism; Adjunct to radio-iodine therapy; Preparation for thyroidectomy
Child: 3-17 yr Initially, 15 mg daily, adjusted according to response.
Renal Dose
N/A
Administration
May be taken with or without food. Take consistently w/ or w/o meals.
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