Indication:

Acute severe asthma, Severe bronchospasm

Pharmacology:
Salbutamol is a synthetic sympathomimetic agent with predominant beta-2 adrenergic activity. Salbutamol produces bronchodilatation through stimulation of beta-2-adrenergic receptors in bronchial smooth muscles, thereby causing relaxation of bronchial muscle fibers. This action is manifested by an improvement in pulmonary function as demonstrated by spirometric measurements.
 
Dosage & Administration:
Salbutamol tablet or syrup-

Adults: 2-4 mg tablet, 3-4 times daily. Maximum single dose is 8 mg tablet.

Children:
2-6 years: 2.5 ml syrup, 3-4 times daily
6-12 years: 5 ml syrup, 3-4 times daily
Over 12 years: 5-10 ml syrup, 3-4 times daily (2-4 mg tablet, 3-4 times daily)

Interaction:
Prolongation of bleeding time and prothrombin time have been reported in some patients receiving Co-amoxiclav. In common with other broad-spectrum antibiotics, Co-amoxiclav may reduce the efficacy of oral contraceptives and patients should be warned accordingly. Concomitant use of allopurinol during treatment with amoxicillin can increase the likelihood of allergic skin reactions. There are no data on the concomitant use of Co-amoxiclav and allopurinol.%

Contraindications:
Hypersensitivity to penicillin has a long history. Cross-sensitivity with other beta-lactam antibiotics, such as cephalosporins, should be considered. Patients with a history of Co-amoxiclav or Penicillin-associated cholestatic jaundice should avoid this medication..
 

Side Effects:
Salbutamol may cause fine tremor of skeletal muscles (particularly the hands), palpitations and muscle cramps. Tachycardia, tenseness, headaches and peripheral vasodilatation have been reported after large doses.

Pregnancy:
Only if the possible benefit outweighs the risk to the fetus should the medicine be used during pregnancy. This medication is not known to be excreted in human milk. Because of the possibility for tumorigenecity revealed in some animal studies for Salbutamol, a decision should be made whether to stop breastfeeding or stop taking the medicine, taking into account the drug's relevance to the mother.

Precautions & Warnings:
Salbutamol should be used with caution in patients with hyperthyroidism, cardiovascular disease, occlusive vascular disorders, hypertension and aneurysms. Hypokalaemia associated with high doses of Salbutamol may result in increased susceptibility to digitalis-induced cardiac arrhythmia. Tachyphylaxis with resistance may occur with prolonged use of high dosage. Care is necessary when treating patients with diabetes mellitus or closed angle glaucoma, and in those receiving antihypertensive therapy.
 
Storage Conditions:
Do not store at temperatures above 30°C. Keep out of children's reach.