The use of undiluted benzydamine Hydrochloride may produce local irritation manifested by burning sensation in patients with mucosal defects. If necessary, it may be diluted (1:1) with lukewarm water. Since it is absorbed from the oral mucosa and excreted mostly unchanged in the urine, a possibility of its systemic action has to be considered in patients with renal impairment.
Indication
Pain or irritation of the mouth and throat, Acute Pharyngitis, Radiation-Associated Mucositis
Contra Indication
Benzydamine Hydrochloride is contraindicated in subjects with a history of hypersensitivity to any of its components.
Dose
N/A
Side Effect
1-10%
Burning /stinging sensation,Nausea/vomiting,Numbness
Frequency Not Defined
Cough,Drowsiness,Dry mouth,Headache,Pharyngeal irritation
Pregnancy Category
Name :
Not Classified
Description
FDA has not yet classified the drug into a specified pregnancy category.
Mode of Action
Benzydamine Hydrochloride predominantly acts by inhibiting the synthesis of pro inflammatory cytokines like tumour necrosis factor-alpha (TNF-?) and interleukin-1? (IL-1?) without largely affecting other pro inflammatory cytokines. Moreover, it is capable of a local anaesthetic effect that may be related to its capability for inhibiting the release of inflammatory mediators like substance P.
Interaction
N/A
Pregnancy Category Note
Pregnancy Category: Not available. Safety has not been established in pregnant women.
Lactation: excretion in milk unknown; use with caution
Adult Dose
Mouth/Throat
Pain or irritation of the mouth and throat, Acute pharyngitis
Adult: Rinse or gargle 15 ml of a 0.15% solution (diluted with water if stinging occurs) every 1? to 3 hours until remission of pain..
Radiation-Associated Mucositis
Gargle or rinse 15 mL in mouth (for 30 seconds, followed by expulsion from mouth) 3-4 times per day
Begin treatment 1 day prior to radiation therapy and continue daily during treatment
Child Dose
N/A
Renal Dose
N/A
Administration
Rinse the 15 ml mouthwash around the mouth or use it as a gargle. After 20 to 30 second, spit it out. Do not swallow the mouthwash.
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