Closalic - 30gm

Oinment

Pack Size : 1 Tube x 1 Packet

Generics : Clobetasol Propionate + Salicylic Acid

Manufacturer : Ziska Pharmaceuticals Ltd.

Best Price * TK 150.00

* Delivery will be done in Dhaka city only.

Alternative Product

Ointment Dermex S Ointment Square Pharmaceuticals Ltd.

Tk 70.00

Oinment Closalic - 10gm Ziska Pharmaceuticals Ltd.

Tk 70.00

Oinment Dermex S - 30gm Opsonin Pharma Ltd.

Tk 150.00

More Information About - Closalic - 30gm

Description

Generic Name

Clobetasol Propionate + Salicylic Acid topical

Precaution

Not for prolonged use in high concentrations and on large areas of the body. Impaired peripheral circulation or diabetes. Avoid broken skin, mouth, eyes, mucous membranes and anogenital region.

Indication

Psoriasis, Burns, Acne vulgaris, Eczema, Dyskeratosis, Ichthyosis, Warts, Hyperkeratosis, Corn, Callus, Seborrhea, Scaly skin disease, Hair loss, Sweating feet, Dermatitis

Contra Indication

Hypersensitivity

Dose

N/A

Side Effect

Prolonged usage of large amount of clobetasol propionate can lead to sufficient systemic levels to produce adrenal suppression, Cushing's syndrome, diabetes and hypertension.Dermal and epidermal atrophy esp on the face, steroid purpura

Pregnancy Category

Name : C

Description

Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks

Mode of Action

Clobetasol Propionate high potency corticosteroid. Corticosteroids decrease inflammation by stabilizing leukocyte lysosomal membranes, preventing release of destructive acid hydrolases from leukocytes; inhibiting macrophage accumulation in inflamed areas; reducing leukocyte adhesion to capillary endothelium; reducing capillary wall permeability and edema formation; decreasing complement components; antagonizing histamine activity and release of kinin from substrates; and reducing fibroblast proliferation, collagen deposition, and subsequent scar tissue formation. Salicylic acid has a potent keratolytic action and a slight antiseptic action when applied topically. It softens and destroys the stratum corneum by increasing endogenous hydration which causes the horny layer of the skin to swell, soften, and then desquamate. At high concentrations, salicylic acid has a caustic effect. It also possesses weak antifungal and antibacterial activity.

Interaction

Clobetasol Propionate: Increased systemic exposure w/ CYP3A4 inhibitors (eg ritonavir & itraconazole).

Pregnancy Category Note

N/A

Adult Dose

Adult: Topical Acne; Hyperkeratotic and scaling skin conditions As 2-6% Salicylic Acid preparation: Apply >3 times/day.

Child Dose

N/A

Renal Dose

N/A

Administration

N/A

Disclaimer

The information provided herein are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please note that this information should not be treated as a replacement for physical medical consultation or advice. Great effort has been placed to provide accurate and comprehensive data. However, Medicart along with its authors and editors make no representations or warranties and specifically disclaim all liability for any medical information provided on the site. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company.