Colostomy, ileostomy; electrolyte imbalance. Monitor for toxicity in patients with impaired renal function. Pregnancy.
Lactation: Use in nursing mothers appears to be safe
Abdominal cramping, Diarrhea, Electrolyte imbalance, Hypotension, Muscle weakness, Respiratory depression, Hypermagnesaemia (in patients with renal impairment). Paralytic ileus.
Pregnancy Category
Name :
A
Description
Adequate and well-controlled human studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
Mode of Action
Magnesium hydroxide increases peristaltic activity causing osmotic retention of fluids, thus resulting in bowel evacuation. It also reduces stomach acid by reacting with hydrochloric acid to form Mg chloride.
Interaction
Decreases absorption of tetracyclines and biphosphonates. Separate administration of these and other drugs by around 2 hr.
Pregnancy Category Note
Pregnancy category: A
Lactation: Use in nursing mothers appears to be safe
Adult Dose
Constipation
Magnesium hydroxide (400 mg/5 mL): 30-60 mL/day PO at bedtime or in divided doses
Acid Indigestion
Magnesium hydroxide (400 mg/5 mL): 5-15 mL PO q4hr; no more than 4 doses per 24-hour period
Child Dose
Constipation
<2 years: Safety and efficacy not established
Suspension
2-6 years: 5-15 mL/day of regular-strength liquid PO at bedtime or in divided doses
6-12 years: 15-30 mL/day (400 mg/5 mL)
>12 years: 30-60 mL/day (400 mg/5 mL)
Acid Indigestion
Liquid
<12 years: Not recommended
>12 years: 5-15 mL (400 mg/5 mL) PO q4hr; no more than 4 doses per 24-hour period
Renal Dose
N/A
Administration
N/A
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