Oxifyl CR 400mg 400mg

Tablet

Pack Size : 10 Tablet x 1 Strip

Generics : Pentoxifylline

Manufacturer : Square Pharmaceuticals Ltd.

Best Price * TK 70.40

* Delivery will be done in Dhaka city only.

Alternative Product

Tablet Oxifyl CR 400mg Square Pharmaceuticals Ltd.

Tk 7.04

More Information About - Oxifyl CR 400mg 400mg

Description

Generic Name

Pentoxifylline

Precaution

Avoid use in patients with severe cardiac arrhythmias or acute MI. Caution when used in patients with ischaemic heart disease or hypotension. Impaired renal or hepatic function. Start at lower dose in elderly; safety and efficacy not established in children. Tablets should not be chewed, crushed or broken; swallow whole. Pregnancy, lactation. Lactation: Drug excreted in breast milk; discontinue therapy, or do not nurse

Indication

Peripheral vascular disease

Contra Indication

Previous hypersensitivity reactions to xanthine-related products e.g. caffeine, theophylline and theobromine. Recent cerebral and/or retinal haemorrhage. Porphyria.

Dose

N/A

Side Effect

1-10% Nausea,Vomiting <1% Angina,Anaphylaxis,Anorexia,Aplastic anemia,Pancytopenia,Conjunctivitis,Angioedema,Aseptic meningitis,Chest pain,Leukemia,Leukopenia,Cholecystitis,Hepatitis,Seizure,Scotoma,Thrombocytopenia,Increased live enzyme Potentially Fatal: Fatal haemorrhage (cerebral and GI tract); anaphylactoid reaction.

Pregnancy Category

Name : C

Description

Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks

Mode of Action

Pentoxifylline reduces blood viscosity by increasing deformability of leukocytes and erythrocytes; and decreasing neutrophil adhesion/activation. It also improves microcirculation and peripheral tissue oxygenation through better blood flow. It has also been used in cerebrovascular disorders.

Interaction

Concurrent use with ciprofloxacin may increase the adverse effect of pentoxifylline. Concurrent use may increase serum levels of theophylline derivatives. Potentially Fatal: May increase risk of adverse effect when used with ketorolac.

Pregnancy Category Note

Pregnancy category: C Lactation: Drug excreted in breast milk; discontinue therapy, or do not nurse

Adult Dose

Oral Peripheral vascular disease Adult: As modified-release formulation: 400 mg tid (normally for at least 8 wk) May reduce to 400 mg bid if GI or CNS adverse effects occur. Intermittent Claudication 400 mg PO q8hr Recommended duration of treatment: >8 weeks Hepatic impairment: Dose reduction may be needed in severe impairment.

Child Dose

Safety and efficacy not established

Renal Dose

Renal impairment: Moderate impairment (CrCl about 60 ml/min): 400 mg bid; Severe impairment (CrCl about 20 ml/min): 400 mg once daily; may reduce further to 400 mg once every other day if needed.

Administration

Should be taken with food.

Disclaimer

The information provided herein are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please note that this information should not be treated as a replacement for physical medical consultation or advice. Great effort has been placed to provide accurate and comprehensive data. However, Medicart along with its authors and editors make no representations or warranties and specifically disclaim all liability for any medical information provided on the site. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company.