Neotracin 500 IU + 5 mg/gm

Ointment

Pack Size : 1 Ointment x 1 Packet

Generics : Bacitracin Zinc + Neomycin Sulphate Eye prep

Manufacturer : Acme Laboratories Ltd.

Best Price * TK 17.42

* Delivery will be done in Dhaka city only.

Alternative Product

More Information About - Neotracin 500 IU + 5 mg/gm

Description

Generic Name

Bacitracin Zinc + Neomycin Sulphate Topical

Precaution

Avoid application in large quantities and prolonged use. Pregnancy and lactation. Liver and renal impairment.

Indication

Bacterial skin infections

Contra Indication

Hypersensitivity to aminoglycosides. Pre-existing nerve deafness. Neonates and infants <2 yr.

Dose

N/A

Side Effect

>10% Allergic contact dermatitis (60%)

Pregnancy Category

Name : C+D

Description

Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks. There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Mode of Action

Neomycin, an aminoglyoside with antimicrobial spectrum similar to gentamicin, binds to the 30S subunits of the bacterial ribosome, inhibiting protein synthesis and thereby disrupting DNA synthesis. It is active against many gram-negative aerobes and against some strains of staphylococci. Bacitracin, on the other hand, inhibits bacterial cell wall synthesis and is active against many gram-positive bacteria (e.g. staphylococci, streptococci, corynebacteria and clostridia) and some gram-negative species (e.g. Neisseria and Haemophilus influenzae). They are often found in combinations in topical preparations as broad spectrum antibacterial agents.

Interaction

Bacitracin Zinc: Increased risk of nephrotoxicity when used with other nephrotoxic drugs. May enhance the action of neuromuscular-blocking agents. Neomycin Sulphate: Additive nephrotoxic and neurotoxic effect w/ other aminoglycosides (e.g. paromomycin), bacitracin, cisplatin, vancomycin, amphotericin B, polymyxin B, colistin and viomycin. Enhanced toxicity w/ potent diuretics (e.g. ethacrynic acid, furosemide). May impair the absorption of other drugs (e.g. phenoxymethylpenicillin, digoxin, methotrexate and some vit). May reduce the efficacy of OCs. May enhance the effect of acarbose. May enhance the effect of non-depolarising muscle relaxants. May antagonise the parasympathomimetic effect of neostigmine and pyridostigmine. May increase the risk of hypocalcaemia in patients receiving bisphosphonates. May alter INR when given w/ anticoagulants. May inactivate oral typhoid vaccine.

Pregnancy Category Note

N/A

Adult Dose

Adult: Topical: Cream: Apply 3 times/day. Powder: Apply 2-4 times/day.

Child Dose

Topical: Cream: Apply 3 times/day. Powder: Apply 2-4 times/day.

Renal Dose

N/A

Administration

N/A

Disclaimer

The information provided herein are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please note that this information should not be treated as a replacement for physical medical consultation or advice. Great effort has been placed to provide accurate and comprehensive data. However, Medicart along with its authors and editors make no representations or warranties and specifically disclaim all liability for any medical information provided on the site. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company.