Severe renal/hepatic/cardiac dysfunction. Porphyria.
Dose
N/A
Side Effect
Vertigo, nausea, vomiting, dry mouth.
Pregnancy Category
Name :
C
Description
Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks
Mode of Action
Drotaverine has antispasmodic effect mediated via inhibition of phosphodiesterase-IV, specific for smooth muscle. It has a rapid and direct action on the smooth muscle. It acts to correct cyclic AMP and Ca imbalance at the spastic site, thereby relieving smooth muscle spasm and pain.
Interaction
May attenuate the action of levodopa. Concurrent use of analgesics, antimuscarinics or benzodiazepines. Additive beneficial effect with concurrent use of analgesics, antimuscarinics or benzodiazepines.
Pregnancy Category Note
N/A
Adult Dose
Oral
As an antispasmodic
Adult: 1 to 2 tablets, 3 times daily.
Injection: Adults: 1 to 2 ampoules, intramuscularly or subcutaneously, 1-3 times daily.
For the management of acute stone colics: 1 or 2 ampoules by slow intravenous injection.
Child Dose
Oral
As an antispasmodic
Children (over 6 years): 1/2 to 1 tablet, 1-2 times daily.
40 mg 1-2 times daily
Children (1-6 years): 1/4 to 1/2 tablet, 1-2 times daily.
20 mg 1-2 times daily
Renal Dose
N/A
Administration
May be taken with or without food.
Disclaimer
The information provided herein are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please note that this information should not be treated as a replacement for physical medical consultation or advice. Great effort has been placed to provide accurate and comprehensive data. However, Medicart along with its authors and editors make no representations or warranties and specifically disclaim all liability for any medical information provided on the site. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company.