Pen-A 250mg

Capsule

Pack Size : 10 Capsule x 1 Strip

Generics : Ampicillin

Manufacturer : Renata Limited

Best Price * TK 21.80

* Delivery will be done in Dhaka city only.

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More Information About - Pen-A 250mg

Description

Generic Name

Ampicillin

Precaution

Renal failure; patients with lymphatic leukaemia or HIV infections; pregnancy and lactation. Lactation: Excreted in breast milk, use caution

Indication

Bacterial infections, Endocarditis, Typhoid fever, Community-acquired pneumonia, Uncomplicated gonorrhea, Susceptible infections, Bacterial meningitis, Paratyphoid fever, Septicaemia, Intrapartum prophylaxis against group B streptococcal infections

Contra Indication

Hypersensitivity; infectious mononucleosis.

Dose

N/A

Side Effect

GI upset, nausea, vomiting, diarrhoea; blood dyscrasias; urticaria, exfoliative dermatitis, rash; fever, seizures; interstitial nephritis. Potentially Fatal: Anaphylactic shock; pseudomembranous colitis; neuromuscular hypersensitivity; electrolyte imbalance.

Pregnancy Category

Name : B

Description

Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.

Mode of Action

Ampicillin exerts bactericidal action on both gm+ve and gm-ve organisms. Its spectrum includes gm+ve organisms eg, S pneumoniae and other Streptococci, L monocytogenes and gm-ve bacteria eg, M catarrhalis, N gonorrhoea, N meningitidis, E coli, P mirabilis, Salmonella, Shigella, and H influenzae. Ampicillin exerts its action by inhibiting the synthesis of bacterial cell wall.

Interaction

May reduce the efficacy of OC. May alter INR while on warfarin and phenindione. May reduce the efficacy of oral typhoid vaccines. May reduce the excretion of methotrexate. Reduced excretion w/ probenecid and sulfinpyrazone, resulting to increased risk of toxicity. Allopurinol increases ampicillin-induced skin reactions. Reduced absorption w/ chloroquine. Bacteriostatic antibacterials (e.g. erythromycin, chloramphenicol, tetracycline) may interfere w/ the bactericidal action of ampicillin.

Pregnancy Category Note

Pregnancy category: B Lactation: Excreted in breast milk; use caution

Adult Dose

Adult: PO Susceptible infections 0.25-0.5 g 6 hrly. Typhoid and paratyphoid fever 1-2 g 6 hrly. Duration: 2 wk (acute infections); 4-12 wk (carriers). Uncomplicated gonorrhoea W/ probenecid: 2 g as single dose. IV/IM: IV Intrapartum prophylaxis against group B streptococcal infections Initial, 2 g, then 1 g 4 hrly until delivery. Septicaemia 150-200 mg/kg/day. Start with IV admin for 3 days, then IM inj 3-4 hrly. Continue treatment for at least 48-72 hr after patient has become asymptomatic or when there is evidence of bacterial eradication. IV/IM Susceptible infections 250-500 mg 6 hrly. Meningitis 2-3 g 4-6 hrly, may start w/ IV admin, then continue w/ IM inj. Inj Supplement to systemic therapy For intrapleural/intraperitoneal/intra-articular admin: 500 mg/day.

Child Dose

Susceptible infections Child: PO: 50?100 mg/kg/day divided q6hr if <20 >20 kg 1?2 g/day divided q6hr IV/IM: Child: 50?200 mg/kg/day q6h 300?400 mg/kg/day endocarditis/meningitis q4?6h

Renal Dose

Renal impairment: Patients undergoing haemodialysis should receive an additional dose after the session. CrCl (ml/min) <10 Dose reduction or increase in dose interval.

Administration

Should be taken on an empty stomach. Take on an empty stomach 1 hr before or 2 hr after meals. Reconstitution: IM: Add 1.5 mL water for inj to 500 mg vial contents. IV: Dissolve 500 mg in 10 mL water for inj.

Disclaimer

The information provided herein are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please note that this information should not be treated as a replacement for physical medical consultation or advice. Great effort has been placed to provide accurate and comprehensive data. However, Medicart along with its authors and editors make no representations or warranties and specifically disclaim all liability for any medical information provided on the site. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company.