Indications:

Tenoren is indicated for the following conditions

• Hypertension
•  Angina Pectoris
• Cardiac Arrhythmia
• Acute Myocardial Infarction

Pharmacology:

Atenolol was created as a result of attempts to create a -adrenoceptor antagonist that would block 1 (cardiac) receptors while having no impact on 2-receptors. It's a 1 selective (cardioselective) -adrenergic receptor antagonist that doesn't have any membranestability or partial agonist action. It is the most hydrophilic of the currently available - blockers, and as a result, it penetrates cell membrane lipids poorly.

Dosage (breakdown or, not) :

Adult: 

Compensated heart failure. Variant angina, acute MI, DM; peripheral vascular disorders; hepatic and renal dysfunction; elderly patients, children. Lactation. If atenolol and clonidine are co-admin, then gradual withdrawal of clonidine should take place a few days after withdrawal of atenolol. Lactation: Drug enters breast milk; neonates born to mothers who are receiving atenolol at parturition or breastfeeding may be at risk for hypoglycemia and bradycardia; use with caution

Child:

Atenolol is a competitive cardioselective beta1-blocker and does not have effect on ?beta2-receptors except in high doses. It reduces resting and exercise-induced heart rate as well as myocardial contractility.

Administration:

Concomitant admin w/ reserpine may increase hypotension and bradycardia. Additive w/ Ca channel blockers, hydralazine, methyldopa. Increased risk of bradycardia and heart block w/ verapamil and diltiazem. May decrease hypotensive effects w/ NSAIDs (e.g. indometacin). Enhanced bradycardic effect w/ disopyramide, amiodarone or digitalis glycosides. May exacerbate rebound HTN upon discontinuance of clonidine treatment.

Interaction:

Hypersensitivity. Sinus bradycardia, sinus node dysfunction, heart block >1st degree, compensated cardiac failure, cardiogenic shock, bronchospastic diseases, peripheral vascular diseases. Pregnancy.

Contraindications:

 Atenolol is contraindicated in sinus bradycardia, heart block greater than first degree, cardiogenic shock, and overt cardiac failure. It is also contraindicated in patients with a history of hypersensitivity to Atenolol or any of the drug product's components.

Side Effect:

Renal impairment: CrCl (ml/min) <15 25 mg or 50 mg on alternate days. 15-35 50 mg/day. Dialysis patients 25-50 mg after each dialysis.

Pregnancy:

 Atenolol can cause fetal harm when administered to a pregnant woman. If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus. Caution should be exercised when Atenolol is administered to a woman, who is breast feeding.

Precautions & Warnings:

 Patients already on a β1 blocker must be evaluated carefully before Atenolol is administered. Initial and subsequent Atenolol dosages can be adjusted downward depending on clinical observations including pulse and blood pressure. Atenolol may aggravate peripheral arterial circulatory disorders.

Storage Conditions:

Do not use after the expiration date. All drugs should be kept out of the reach of youngsters. Only on a licensed physician's prescription can it be dispensed.