Pancreatin
Avoid high doses in patients with cystic fibrosis. Maintain adequate hydration. Some products contain pork protein. Inactivated by heat; do not mix with hot food or liquids. May irritate oral mucosa; should not be held in mouth. Pregnancy and lactation.
Pancreatic insufficiency
Acute pancreatitis or acute exacerbation of chronic pancreatic disease.
N/A
GI effects e.g. abdominal discomfort, nausea and vomiting. Buccal and perianal irritation, particularly in infants. Colonic strictures may occur, mainly in children with cystic fibrosis receiving high doses of pancreatin preparations. Hyperuricaemia and hyperuricosuria may occur.
Pancreatin are pancreatic enzymes which hydrolyse fats to glycerol and fatty acids, break down protein into peptides, proteoses and derived substances, and convert starch into dextrins and sugars.
May impair the oral absorption of folic acid when taken together; antagonises hypoglycaemic effect of acarbose.
Pregnancy Category: C Lactation: not known if excreted in breast milk; effect on nursing infant not known
Oral Pancreatic insufficiency Adult: PO 1-3 tablets daily with meal.
N/A
N/A
N/A
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