Generic Name

Diosmin + Hesperidin

Precaution

Pregnancy & Lactation.

Indication

Hemorrhoids, Piles, Chronic venous disease

Contra Indication

It is contra-indicated in patients, who have shown hypersensitivity to any of the substances present in the drug.

Dose

N/A

Side Effect

Possible side-effects to be observed: cutaneous allergies, gastrointestinal disorders, headaches and flushes.

Pregnancy Category

Mode of Action

Diosmin and hesperidin are flavonoid compounds. When used together, they prolong the vasoconstrictor effect of noradrenaline on the venous wall, thus increasing venous return and reducing venous hyperpressure present in patients with chronic venous disease. They also improve lymphatic drainage and protect the microcirculation from inflammation. Diosmin and hesperidin are used together in the treatment of venous disease e.g. chronic venous disease and haemorrhoidal disease.

Interaction

Metabolism of metronidazole may be reduced by concurrent admin of diosmin.

Pregnancy Category Note

N/A

Adult Dose

Oral Chronic venous disease Adult: Each tablet containing disomin 450 mg and hesperidin 50 mg: 2 tablets daily for 2-6 months. Each tablet containing disomin 900 mg and hesperidin 100 mg: 1 tablet daily for 2-6 months. Haemorrhoids Adult: Acute attack: disomin 450 mg and hesperidin 50 mg: 6 tablets daily for the 1st 4 days followed by 4 tablets daily for the next 3 days. DS Tablet: disomin 900 mg and hesperidin 100 mg: 1 tablet 3 times daily for 4 days then 2 times daily for 3 days and Once daily as maintenance Chronic haemorrhoids: disomin 450 mg and hesperidin 50 mg: 2 tablets daily for 3 months. DS Tablet: disomin 900 mg and hesperidin 100 mg: 1 tablet once daily for 3 months

Child Dose

N/A

Renal Dose

N/A

Administration

N/A