Generic Name

Clotrimazole 1% Topical

Precaution

Avoid contact with eyes upon topical application. Childn <3 yrs. Pregnancy, lactation.If local intolerance develops, consider withdrawal of the medicine and institution of appropriate therapy. Lactation: Excretion in milk unknown; use with caution

Indication

Skin and nail fungal infections, Tinea pedis, Tinea cruris, Tinea corporis, Candidiasis, Pityriasis versicolor

Contra Indication

Hypersensitivity.

Dose

N/A

Side Effect

Elevated serum AST (SGOT) concentrations (15%) Topical: Erythema, stinging, irritation; hypersensitivity reactions; contact dermatitis. Edema, Pruritus, Burning, Stinging, Peeling, Urticaria, Skin fissures

Pregnancy Category

Mode of Action

Clotrimazole is a broad-spectrum antifungal which binds to phospholipids in the cell membrane altering cell wall permeability causing a loss in essential intracellular elements.

Interaction

Antagonism with polyene antibiotics.

Pregnancy Category Note

Pregnancy Small amounts of imidazoles may be absorbed systemically following topical and vaginal administration Lactation Excretion in milk unknown; use with caution

Adult Dose

Topical/Cutaneous Skin and nail fungal infections: Adult: Apply 2 or 3 times daily. Onychomycosis: for 6 months. Tinea pedis & Dermatomycoses: for 4 weeks.

Child Dose

Tinea Corporis/Tinea Pedis Apply to affected area q12hr for 4 weeks Tinea Cruris >2 years: Apply to affected area q12hr for 2 weeks Candidiasis Gently massage sufficient clotrimazole into affected and surrounding area q12hr; reconsider diagnosis if no improvement after 4 weeks Tinea Versicolor Gently massage sufficient clotrimazole into affected and surrounding area q12hr; reconsider diagnosis if no improvement after 4 weeks

Renal Dose

N/A

Administration

N/A