Indications Evening primrose oil is indicated in: Premenstrual syndrome symptoms (PMS) Cyclical mastalgia Lactation Therapeutic Class Herbal and Nutraceuticals Description Evening Primrose is a plant native to North America. It was one of the first medicinal plants brought back to Europe by settlers in the 16th century. Evening primrose oil (EPO) has been the subject of hundreds of scientific studies, which led to it becoming one of the most widely used botanical medicines today. EPO is sold in over 30 countries as a dietary supplement, drug or food. In 2000, Evening primrose oil ranked 10th of all herbal dietary supplements in U.S. food, drug and mass-market retail outlets.Clinical studies have focused on its use in treating problems associated with essential fatty acid (EFA) deficiency including premenstrual syndrome, atopic eczema, inflammation and diabetic peripheral neuropathy. EPO is relatively high in essential fatty acids (EFAs), particularly gamma-linolenic acid (GLA, 7-10%).Evening primrose oil preparations consist of a clear, golden yellow, fixed oil extracted by cold expression or solvent extraction, from the seeds of Oenothera biennis L., which first occur during the second year of plant growth. Evening primrose oil is a biennial herb, infertile for the first year. Pharmacology Improves EFA composition of plasma, erythrocyte, platelet lipids and ?-tocopherol levels in non-diabetic persons and Type 1 diabetic patients; increases total fat and EFA content of mother's milk; affects fatty acid composition of serum lipids and adipose tissue in men with low dihomo-gamma-linolenic acid (DGLA) levels; helps maintain normal cellular structures and is the precursor of DGLA, which is the parent of the 1-series prostanoids and as a precursor of arachidonic acid, the parent of the 2-series prostanoids. In vitro: Cytostatic activity on malignant cell lines; suppresses cancer cell proliferation of human osteogenic sarcoma cells.Evening primrose oil (EPO) supplies gamma linolenic acid (GLA). The bioactivity of EPO is due primarily to its GLA content. By supplying GLA, it bypasses the rate-limiting step in the metabolism of LA. After ingestion of EPO, GLA is rapidly absorbed and then converts directly to DGLA and other prostaglandin precursors. It also acts on the prostanoid pathway. Dosage & Administration One or two capsules two to three times daily or as advised by the physician. Interaction There are no known drug interactions. Steroids and nonsteroidal anti-inflammatory drugs may potentially interfere with essential fatty acid metabolism. Side Effects Adverse effects are rare at recommended dosages. Overdose may cause loose stool and abdominal pain. Pregnancy & Lactation No known restrictions. Non-teratogenic, based on animal studies. LA, GLA, and DGLA are important components of human breast milk, so it is reasonable to assume that evening primrose oil may be taken while nursing. According to World Health Organization (WHO), pregnant or lactating women should get 5% of their total daily caloric intake from EFAs. Storage Conditions Keep below 30?C temperature, away from light & moisture. Keep out of the reach of children. Alternative brand for Rose 500 Sorted by Price ? Primacap 500 delivery type mark Primacap 500 Drug International Ltd. Save 11% description Disclaimer The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.