Nystatin
Immunocompromised patients. Childn. Pregnancy and lactation. Patient Counselling May damage latex contraceptives (vag). Lactation: Not known if excreted in breast milk; use caution
Fungal infections, Oropharyngeal candidiasis, Intestinal candidiasis, Vaginal candidiasis
Hypersensitivity.
N/A
Nausea, vomiting, diarrhoea, GI upset, oral irritation and sensitisation. Rarely, rash, urticaria, Stevens-Johnson syndrome, tachycardia, bronchospasm, facial swelling, nonspecific myalgia Vaginal tablet: May damage latex contraceptives (e.g. diaphragms, condoms), additional contraceptive measures should be taken. Localized sensitization.
Nystatin, a polyene antifungal, binds to ergosterol in the fungal cell membrane. This binding affects the cell wall permeability allowing leakage of cellular contents.
N/A
Pregnancy category: C, ROUTE(S) : Mouth/Throat / PO Pregnancy Category: A, ROUTE(S) : Vaginal
Oral Oral candidiasis Adult: As oral susp or drop : 100,000-600,000 U (1-6 ml drop) into the mouth 4 times daily. Keep in contact w/ affected area as long as possible. Continue for 48 hr after clinical cure to prevent relapse. Intestinal candidiasis Adult: As tab or oral susp/drop: 500,000 or 1,000,000 U 3-4 times daily. Prophylaxis: 1,000,000 U daily. Vaginal Vulvovaginal candidiasis Adult: insert 1 vaginal tablet into vagina daily at bedtime for 14 days or longer.
As oral susp or drop Infants: PO: 2 mL/dose, children 4–6 mL/dose, to coat oral mucosa q6h As tab Child: PO: 3–6 tabs/day tid For prophylaxis of oral candidiasis in the newborn the suggested dose is 1 ml (100,000 U) once daily. Administration should be continued for 48 hours after clinical cure to prevent relapse.
N/A
May be taken with or without food.
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