Cystitis and pyelonephritis
Cystitis, pyelonephritis, or other upper UTI may occur
Avoid use of in females of reproductive potential with a history of recurrent UTI or urinary tract abnormalities
Indication
Contraception, To prevent pregnancy
Contra Indication
Should be avoided in women who have had recurrent urinary tract infections or abnormalities or are using a vaginal ring.
FDA has not yet classified the drug into a specified pregnancy category.
Mode of Action
Vaginal pH range is 3.5-4.5 and semen pH range is 7.2-8
Introduction of semen into the vagina causes increased pH (>6) owing to ejaculate alkalinity; the alkaline pH neutralizes the normally acidic vaginal environment allowing spermatozoa survival
Vaginal pH lowering effect of lactic acid/citric acid/potassium bitartrate causes reduced sperm motility and contributes to intravaginal contraceptive activity
Interaction
N/A
Pregnancy Category Note
Pregnancy
Do not use during pregnancy
Discontinue during pregnancy
No data available with the use in pregnant females or animals
Lactation
No data available on the presence of lactic acid, citric acid, and potassium bitartrate or their metabolites in human milk, or effects on breastfeeding or milk production
Adult Dose
Contraception
Indicated for prevention of pregnancy in females of reproductive potential for use as an on-demand contraceptive method
Apply 1 prefilled applicator (5 grams) vaginally immediately before or up to 1 hr before each act of vaginal intercourse
If >1 act of vaginal intercourse occurs within 1 hr, an additional dose must be applied
Child Dose
N/A
Renal Dose
N/A
Administration
Intravaginal Administration
May use during any part of the menstrual cycle
May use as soon as it is safe to resume vaginal intercourse after childbirth, abortion, or miscarriage
Disclaimer
The information provided herein are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please note that this information should not be treated as a replacement for physical medical consultation or advice. Great effort has been placed to provide accurate and comprehensive data. However, Medicart along with its authors and editors make no representations or warranties and specifically disclaim all liability for any medical information provided on the site. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company.