More Information About - Moodnor 10 mg Tab. - 10 mg
Description
Generic Name
Nortriptyline
Precaution
Not intended for treatment of bipolar depression. Avoid abrupt withdrawal. Patient at risk of seizures, w/ DM, narrow angle glaucoma, urinary retention, prostatic hyperplasia, chronic constipation, history of CV disease. Renal and hepatic impairment. Elderly, childn. Pregnancy and lactation. Patient Counselling May impair ability to perform tasks requiring mental and physical alertness (e.g. driving or operating machinery). Monitoring Parameters Monitor BP and pulse rate prior to or during initial therapy, wt. Monitor for emergence of serotonin syndrome. Closely monitor for clinical worsening, suicidality and unusual changes in behaviour.
Lactation: Excreted in breast milk; do not nurse (AAP states effect on nursing infants is unknown but may be of concern)
Indication
Depression, Nocturnal enuresis
Contra Indication
Mania, recent MI, arrhythmias (particularly heart block); severe liver disease; children <6 yr.
Dose
N/A
Side Effect
Hypotension, HTN, tachycardia, palpitation, MI, arrhythmias, heart block, stroke; confusional states w/ hallucinations, disorientation, delusions; anxiety, restlessness, agitation; insomnia, panic, nightmares; hypomania; exacerbation of psychosis; suicidal ideation and behaviours; numbness, tingling, paraesthesia; incoordination, ataxia, tremors; peripheral neuropathy; extrapyramidal symptoms; seizures; tinnitus, dry mouth, blurred vision, accommodation disturbances, mydriasis; constipation, paralytic ileus; urinary retention, delayed micturition, dilation of the urinary tract.
Rash, itching, urticaria, photosensitisation; oedema (general or of face and tongue); bone-marrow depression including agranulocytosis, aplastic anaemia, eosinophilia, thrombocytopenia. Nausea, vomiting, anorexia, epigastric distress, diarrhoea, peculiar taste, stomatitis, abdominal cramps, malaise, jaundice, hepatitis and liver necrosis. Sweating, flushing, urinary frequency, nocturia, drowsiness, dizziness, weakness, fatigue, headache, parotid swelling, alopecia.
Gynaecomastia, breast enlargement and galactorrhoea; increased or decreased libido, impotence, testicular swelling; elevation or reduction of blood sugar levels; inappropriate secretion of antidiuretic hormone syndrome. Wt gain or loss, altered liver function. Rarely, associated sublingual adenitis or gingivitis.
Potentially Fatal: Rare, blood dyscrasias.
Pregnancy Category
Name :
C
Description
Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks
Mode of Action
Nortriptyline, a dibenzocycloheptadiene tricyclic antidepressant, is the primary active metabolite of amitriptyline. It increases synaptic concentration of serotonin and/or norepinephrine in the CNS by blocking the neuronal reuptake of norepinephrine and serotonin.
Interaction
Increased risk of serotonin syndrome w/ SSRIs, SNRIs, TCAs, triptans, fentanyl, lithium, tramadol, tryptophan, buspirone. May reduce antihypertensive effect of bethanidine, guanethidine, debrisoquine, clonidine. May increase metabolism w/ barbiturates. Increased risk of arrhythmias and hypotension w/ anaesth. Increased plasma level w/ fluoxetine.
Potentially Fatal: Increased risk of serotonin syndrome w/ MAOIs, linezolid and methylene blue.
Pregnancy Category Note
N/A
Adult Dose
Oral
Depression
Adult: 75-100 mg/day in 3 or 4 divided doses. Max: 150 mg/day in severe depression.
Elderly: 30-50 mg/day in divided doses.
Hepatic impairment: Administer lower dose and titrate at a slower rate
Child Dose
Oral
Depression
Child: Adolescent: 30-50 mg/day in divided doses.
Nocturnal enuresis
Child: 6-7 yr (20-25 kg): 10 mg;
8-11 yr (25-35kg): 10-20 mg;
>11 yr (35-54 kg): 25-35 mg.
All doses are given 30 minutes before bedtime and treatment should continue for not >3 mth.
Renal Dose
N/A
Administration
May be taken with or without food.
Disclaimer
The information provided herein are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please note that this information should not be treated as a replacement for physical medical consultation or advice. Great effort has been placed to provide accurate and comprehensive data. However, Medicart along with its authors and editors make no representations or warranties and specifically disclaim all liability for any medical information provided on the site. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company.