Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks
Mode of Action
Hyoscine competitively blocks muscarinic receptors and has central and peripheral actions. It relaxes smooth muscle and reduces gastric and intestinal motility.
Interaction
Additive sedative effects with alcohol or other CNS depressants. Reduced effects with acetylcholinesterase inhibitors (donepezil, galantamine, rivastigmine, tacrine).
Potentially Fatal: Effect potentiated by other anticholinergic drugs and TCAs.
Pregnancy Category Note
N/A
Adult Dose
Adult: Motion sickness As hydrobromide: 300 mcg 30 mins before journey, then 300 mcg 6 hrly if needed.
Max: 3 doses in 24 hr.
Child Dose
Children over 12 years: Motion sickness As hydrobromide: 300 mcg 30 mins before journey, then 300 mcg 6 hrly if needed.
Max: 3 doses in 24 hr.
Children 4-12 years: 1 tablet 30 mins before journey. Maximum 2 tablet in 24 hours.
Chidren 3-4 years: 1/2 tab 30 mins before journey. Maximum 1 tablet in 24 hours.
Renal Dose
N/A
Administration
N/A
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