Constipation, Bowel evacuation before investigational procedures
Contra Indication
Acute inflammatory bowel diseases, severe dehydration, ileus or intestinal obstruction, severe painful and/or feverish acute abdominal conditions (e.g. appendicitis) potentially associated w/ nausea and vomiting.
Dose
Oral
Constipation
Adult: 5-10 mg as a single dose, usually at bedtime.
Child: 1 mth to <4 yr 0.25 mg/kg. Max: 5 mg; 4-10 yr 2.5-5 mg; >10 yr 5-10 mg. Doses are usually given at night.
Bowel evacuation before investigational procedures
Adult: 10 mg, w/ Mg citrate, given in the morning and again in the afternoon of the day before examination.
Child: 1 mth to <4 yr 0.25 mg/kg. Max: 5 mg; 4-10 yr 2.5-5 mg; >10 yr 5-10 mg. Doses are usually given at night.
FDA has not yet classified the drug into a specified pregnancy category.
Mode of Action
Sodium picosulfate is a locally acting laxative which has a dual action of stimulating the mucosa of both the large intestine causing colonic peristalsis and of the rectum causing increased motility and a feeling of rectal fullness.
Interaction
Increased risk of electrolyte imbalance w/ diuretics or adreno-corticosteroids. Increased sensitivity to cardiac glycosides resulting from electrolyte imbalance. Reduced laxative action w/ antibiotics.
Pregnancy Category Note
N/A
Adult Dose
Oral
Constipation
Adult: 5-10 mg as a single dose, usually at bedtime.
Bowel evacuation before investigational procedures
Adult: 10 mg, w/ Mg citrate, given in the morning and again in the afternoon of the day before examination.
Child Dose
Oral
Constipation
Child: 1 mth to <4 yr 0.25 mg/kg. Max: 5 mg; 4-10 yr 2.5-5 mg; >10 yr 5-10 mg. Doses are usually given at night.
Bowel evacuation before investigational procedures
Child: 1 mth to <4 yr 0.25 mg/kg. Max: 5 mg; 4-10 yr 2.5-5 mg; >10 yr 5-10 mg. Doses are usually given at night.
Renal Dose
N/A
Administration
May be taken with or without food.
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