Nodia 10mg Tab. - 10mg

Tablet

Pack Size : 10 Tablet x 1 Strip

Generics : Leflunomide

Manufacturer : Incepta Pharmaceuticals Ltd.

Best Price * TK 30.00

* Delivery will be done in Dhaka city only.

Alternative Product

More Information About - Nodia 10mg Tab. - 10mg

Description

Generic Name

Leflunomide

Precaution

Renal and hepatic impairment; Women with childbearing potential. Caution should be taken for those female with child bearing potential who are not using reliable contraception and for the subject of renal insufficiency. Leflunomide should be stopped before becoming pregnant. Liver function should be monitored before starting treatment. Monitor blood counts and BP regularly. Avoid alcohol. Lactation: not known if excreted in breast milk

Indication

Rheumatoid arthritis, Psoriatic arthritis

Contra Indication

Significant hepatic impairment, compromised immune function including bone marrow dysplasia or severe uncontrolled infection; concurrent vaccination with live vaccines. Pregnancy, lactation.

Dose

N/A

Side Effect

>10% Diarrhea (17%),Respiratory infections (15%) 1-10% (selected) Alopecia (10%),Hypertension (10%),Rash (10%),Nausea (9%),Bronchitis (7%),Headache (7%),Abdominal pain (5%),Abnormal LFT's (5%),Accidental injury (5%),Back pain (5%),Dyspepsia (5%),UTI (5%),Dizziness (4%),Infection (4%),Joint disorder (4%),Pruritus (4%),Weight loss (4%),Anorexia (3%),Cough (3%),Gastroenteritis (3%),Pharyngitis (3%),Stomatitis (3%),Tenosynovitis (3%),Vomiting (3%),Weakness (3%),Allergic reaction (2%),Chest pain (2%),Dry skin (2%),Eczema (2%),Pain (2%),Paresthesia (2%),Pneumonia (2%),Rhinitis (2%),Sinusitis (2%),Synovitis (2%) Potentially Fatal: Hepatotoxicity.

Pregnancy Category

Name : X

Description

Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.

Mode of Action

Leflunomide is an immunomodulating agent and DMARD. It inhibits pyrimidine synthesis by inhibiting dihydroorotate dehydrogenase enzyme activity resulting in antiproliferative and anti-inflammatory effects.

Interaction

Cholestyramine and activated charcoal may decrease plasma concentration of active metabolite. Concurrent use of methotrexate and other hepatotoxic drugs may increase the risk of hepatotoxicity. Rifampicin increases serum levels of the active metabolite. Potentially Fatal: May enhance the adverse effects of live vaccines.

Pregnancy Category Note

Pregnancy Category: X Lactation: not known if excreted in breast milk

Adult Dose

Oral Rheumatoid arthritis; Psoriatic arthritis Adult: Loading dose: 100 mg once daily for 3 days. Maintenance: 10-20 mg once daily. Hepatic impairment: Contraindicated.

Child Dose

Safety and efficacy not established

Renal Dose

Renal impairment: Mild: No dosage adjustment needed. Moderate to Severe: Contraindicated.

Administration

May be taken with or without food.

Disclaimer

The information provided herein are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please note that this information should not be treated as a replacement for physical medical consultation or advice. Great effort has been placed to provide accurate and comprehensive data. However, Medicart along with its authors and editors make no representations or warranties and specifically disclaim all liability for any medical information provided on the site. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company.