Maxrin D 500/400 mcg Cap. - 0.4/0.5mg

Capsule

Pack Size : 10 Capsule x 1 Strip

Generics : Tamsulosin Hydrochloride + Dutasteride

Manufacturer : Square Pharmaceuticals Ltd.

Best Price * TK 200.00

* Delivery will be done in Dhaka city only.

Alternative Product

Capsule Prostacin D - 400mcg Incepta Pharmaceuticals Ltd.

Tk 20.00

More Information About - Maxrin D 500/400 mcg Cap. - 0.4/0.5mg

Description

Generic Name

Tamsulosin + Dutasteride

Precaution

Excreted in semen therefore use of condom is recommended. Women of childbearing potential should avoid handling leaking capsules of dutasteride. Prostate carcinoma should be ruled out before starting the therapy. Blood donation to be avoided during and at least 6 mths after discontinuance of drug.

Indication

Benign prostatic hyperplasia

Contra Indication

Hypersensitivity, severe liver impairment. Pregnancy, lactation, child, adolescent.

Dose

N/A

Side Effect

>10% Orthostasis (16%) 1-10% Ejaculation disorders (10%),Dizziness (2%),Breast enlargement/tenderness (3%),Impotence (8%),Decreased libido (4.5%),Breast disorders (1%) <1% Prostate cancer (high grade)

Pregnancy Category

Name : X

Description

Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.

Mode of Action

Tamsulosin is a selective alpha-1 adrenoceptor blocker. It blocks alpha-1 adrenoceptors, which are abundant in the prostate, prostatic capsule, prostatic urethra, and bladder neck, resulting relaxation of these adrenoceptors in the bladder neck and prostate. Thus, there is an improvement in urine flow rate and reduction in symptoms of benign prostatic hypertrophy (BPH). Dutasteride inhibits 5 alpha-reductase, the enzyme responsible for conversion of testosterone to 5 alpha-dihydrotestosterone (DHT). DHT appears to be the principal androgen responsible for stimulation of prostatic growth.

Interaction

Concomitant admin with moderate or strong inhibitors of CYP2D6 (eg. fluoxetine) or CYP34A (eg. ketoconazole, cimetidine) increases tamsulosin serum concentration; increase in blood concentrations of dutasteride in the presence of inhibitors of CYP3A4/5 such as ritonavir, ketoconazole, verapamil, diltiazem, cimetidine, troleandomycin, and ciprofloxacin.

Pregnancy Category Note

Pregnancy Category: X Lactation: Unknown whether distributed in breast milk, contraindicated in breastfeeding women

Adult Dose

Oral Benign prostatic hyperplasia Adult: 1 cap once daily.

Child Dose

N/A

Renal Dose

N/A

Administration

N/A

Disclaimer

The information provided herein are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please note that this information should not be treated as a replacement for physical medical consultation or advice. Great effort has been placed to provide accurate and comprehensive data. However, Medicart along with its authors and editors make no representations or warranties and specifically disclaim all liability for any medical information provided on the site. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company.