Citicoline seems to be safe when taken short-term (up to 90 days). The safety of long-term use is not known. Most people who take citicoline don't experience problematic side effects. But some people can have side effects such as trouble sleeping (insomnia), headache, diarrhea, low or high blood pressure, nausea, blurred vision, chest pains, and others.
Pregnancy Category
Name :
Not Classified
Description
FDA has not yet classified the drug into a specified pregnancy category.
Mode of Action
Citicoline increases blood flow and O2 consumption in the brain. It is also involved in the biosynthesis of lecithin.
Citicoline activates the bio?synthesis of structural phospholipids in the neuronal membrane, increases cerebral metabolism and increases the level of various neurotransmitters, including acetylcholine and dopamine.
Citicoline has shown neuro?protective effects in situations of hypoxia and ischaemia, as well as improved learning and memory performance in animal models for the brain aging.
Furthermore, it has been demonstrated that Citicoline restores the activity the activity of mitochondrial ATPase and of membranal Na+/K+ATPase, inhibits the activation of phospholipase A2 and accelerates the re?absorption of cerebral edema in various experimental models.
Interaction
N/A
Pregnancy Category Note
N/A
Adult Dose
Oral
Head injury; Cerebrovascular disorders; Parkinsonism
Adult: 200-600 mg daily in divided doses.
Parenteral
Head injury; Cerebrovascular disorders; Parkinsonism
Adult: Up to 1 g IM/IV daily.
Child Dose
N/A
Renal Dose
N/A
Administration
May be taken with or without food. Take w/ or between meals.
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